Email this article PROTEIN TOXINS OF STAPHYLOCOCCUS AUREUS
- Authors: Shamsutdinov A.F1, Tyurin Y.A2
-
Affiliations:
- Kazan Research Institute of Epidemiology and Microbiology, Russia
- Kazan Research Institute of Epidemiology and Microbiology, Kazan State Medical University, Russia
- Issue: Vol 91, No 2 (2014)
- Pages: 113-120
- Section: Articles
- URL: https://microbiol.crie.ru/jour/article/view/13965
- ID: 13965
Cite item
Full Text
Abstract
Main scientific-research studies regarding protein bacterial toxins of the most widespread bacteria that belong to Staphylococcus spp. genus and in particular the most pathogenic species for humans - Staphylococcus aureus, are analyzed. Structural and biological properties of protein toxins that have received the name of staphylococcus pyrogenic toxins (PTSAg) are presented. Data regarding genetic regulation of secretion and synthesis of these toxins and 3 main regulatory genetic systems (agr - accessory gene regulator, xpr - extracellular protein regulator, sar - staphylococcal accessory regulator) that coordinate synthesis of the most important protein toxins and enzymes for virulence of S. aureus, are presented.
Keywords
About the authors
A. F Shamsutdinov
Kazan Research Institute of Epidemiology and Microbiology, Russia
Yu. A Tyurin
Kazan Research Institute of Epidemiology and Microbiology, Kazan State Medical University, Russia
References
- Вертиев Ю.В. Бактериальные токсины: биологическая сущность и происхождение. Журн. микробиол. 1996, 3: 43-46.
- Далин М.В., Фиш Н.Г. Белковые токсины микробов. М., Медицина. 1980.
- Дмитренко О.А., Прохоров В.Я., Шагинян И.А., Флуер Ф.С., Суборова Т.Н., Волков И.И., Карабак В.И., Гинцбург А.Л. Определение генов пирогенных токсинов суперантигенов у клинических изолятов метициллинрезистентных Staphylococcus aureus. Журн. микробиол. 2006, 2: 36-42.
- Зуева В.С., Дмитренко О.А., Акатов А.К., Крупина Е.С. Метициллинрезистентные стафилококки - возбудители внутрибольничной инфекции. В: Госпитальные инфекции и лекарственная устойчивость микроорганизмов. Сб. научн. трудов. М., 1992.
- Супотницкий М.В. Бактериальные токсины. Их природа, механизмы действия, возможности конструирования гибридных и модифицированных токсинов. Биопрепараты. 2011, 1: 6-15.
- Супотницкий М.В. Микроорганизмы, токсины и эпидемии. М., 2000.
- Флуер Ф.С., Дмитренко О.А., Прохоров В.Я., Вертиев Ю.В., Охлопкова К.А. Энтеротоксигенность штаммов стафилококков, выделенных от больных сепсисом, пневмонией и ожоговой болезнью. Журн. микробиол.2003, 3: 99-109.
- Bhakdi S., Bayley H., Valeva A. et al. Staphylococcal alpha-toxin, streptolysin-O and Escherichia coli hemolysin: prototypes of pore-forming bacterial cytolysins. Arch. Microbiol. 1996, 165 (1): 7379.
- Finlay B., Falkow S. Common themes in microbial pathogenicity. Microbiol. Rev. 1997, 53 (2): 210230.
- Fraser J.D., Proft T. The bacterial superantigen and superantigen-like proteins. Immunol. Rev. 2008, 225: 226-243.
- Henkel J.S., Baldwin M.R., Barbieri J.T. Toxins from bacteria. EXS. 2010, 100: 1-29
- Holtfreter S., Broker B. M. Staphylococcal superantigens: do they play a role in sepsis? Arch. Immunol. Ther. Exp. 2005, 53: 13-27.
- Larkin E.A., Carman R.J., Krakauer T., Stiles B.G. Staphylococcus aureus: the toxic presence of a pathogen extraordinaire. Curr. Med. Chem. 2009, 16 (30): 4003-4019.
- Rago J. V., Curr Top P.M. Mechanisms of pathogenesis of staphylococcal and streptococcal superantigens.Microbiol. Immunol. 1998, 225: 81-97.
- Schiavo G., Montecucco C. The structure and mode of action of botulinum and tetanus toxins. In: The clostridia: molecular biology and pathogenesis. Rood J., McClane B., Songer J., Titball R. (ed.). San Diego, Academic Press, 1997, p. 295-322.
- Schlievert P. Searching for superantigens. Immunol. Infect. 1997, 26 (2): 283-290.
- Schlievert P.M., Case L.C. Molecular analysis of staphylococcal superantigens. Methods Mol. Biol. 2007, 391: 113-126.
- Schmitt C.K., Meysick K.C., Brien A.D. Bacterial toxins: friends or foes? Emerg. Infect. Dis. 1999, 5 (2): 224-234.
- Schmitz F. J., Steiert M., Hofmann B. et al. Development of a multiplex-PCR for direct detection of the genes for enterotoxin B and C and toxic shock syndrome toxin-1 in Staphylococcus aureus isolates. J. Med. Microbiol. 1998, 47: 335-340.
- Williams R.J., Ward J.M., Henderson B. et al. Identification of a novel gene cluster encoding staphylococcal exotoxin-like proteins: Characterization of the prototypic gene and its protein product, SET1. Infect. Immun. 2000, 68: 4407-4415.
- Wines B.D., Willoughby N., Fraser J.D., Hogarth P.M. A competitive mechanism for staphylococcal toxin SSL7 inhibiting the leukocyte IgA receptor, Fc alphaRI, is revealed by SSL7 binding at the C alpha2/C alpha3 interface of IgA. J. Biol. Chem. 2006, 281: 1389-1393.
Supplementary files
