GROUP ENTEROVIRUS INFECTION DUE TO COXSACKIEVIRUS A16 IN NORTHWESTERN RUSSIA

  • Authors: Bichurina M.A1, Romanenkova N.I1, Novikova N.A2, Golitsyna L.N2, Rozaeva N.R1, Kanaeva O.I1, Ermakova M.V3, Kamynina L.S4, Madoyan A.G5, Valdaitseva N.V6, Leonova N.P7, Ivanova T.G8
  • Affiliations:
    1. Pasteur Research Institute of Epidemiology and Microbiology, St. Petersburg, Russia
    2. Blokhina Research Institute of Epidemiology and Microbiology, Nizhny Novgorod, Russia
    3. Administration of the Federal Service of Surveillance for Protection of Consumers Rights and Human Welfare for Murmansk Region, Russia
    4. Centre of Hygiene and Epidemiology in Murmansk Region, Murmansk, Russia
    5. Administration of the Federal Service of Surveillance for Protection of Consumers Rights and Human Welfare for Leningrad Region, Russia
    6. Centre of Hygiene and Epidemiology in Leningrad Region, St. Petersburg, Russia
    7. Administration of the Federal Service of Surveillance for Protection of Consumers Rights and Human Welfare for Novgorod Region, Russia
    8. Centre of Hygiene and Epidemiology in Novgorod Region, Veliky Novgorod, Russia
  • Issue: Vol 91, No 2 (2014)
  • Pages: 51-58
  • Section: Articles
  • URL: https://microbiol.crie.ru/jour/article/view/13938
  • ID: 13938

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Abstract

Aim. Study features of epidemic process and etiology of oral cavity and limb enterovirus exanthema group diseases in a number of territories of Northwestern Russia. Materials and methods. Isolation and identification of non-poliomyelitis enteroviruses from material of patients was carried out according to WHO recommendations. Phenotyping and phylogenetic analysis of enteroviruses was carried out. Results. In 3 territories of Northwestern Russia oral cavity and limb enterovirus group diseases were registered. Children aged less than 14 years, predominately aged less than 3 years, were shown to be involved in the epidemic process. Coxsackie A16 enteroviruses from 27 samples of patients were isolated in cell cultures and identified by using specific sera. Coxsackie A16 enteroviruses from 16 samples were identified by using partial sequencing of VP1 genome area. Phylogenetic analysis has shown that the identified Coxsackie A16 viruses distributed among 2 phylogenetic groups. Conclusion. Coxsackie A16 enteroviruses that had never been detected in the region previously were established to be the etiologic factor of oral cavity and limb enterovirus exanthema group disease in the 3 territories of Northwestern Russia. The data obtained give evidence on the necessity of epidemiologic and virological control for enterovirus infection with the aim of obtaining novel information on the circulation of non-poliomyelitis enteroviruses in the population and the establishment of development patterns for epidemic process of this infection.

About the authors

M. A Bichurina

Pasteur Research Institute of Epidemiology and Microbiology, St. Petersburg, Russia

N. I Romanenkova

Pasteur Research Institute of Epidemiology and Microbiology, St. Petersburg, Russia

N. A Novikova

Blokhina Research Institute of Epidemiology and Microbiology, Nizhny Novgorod, Russia

L. N Golitsyna

Blokhina Research Institute of Epidemiology and Microbiology, Nizhny Novgorod, Russia

N. R Rozaeva

Pasteur Research Institute of Epidemiology and Microbiology, St. Petersburg, Russia

O. I Kanaeva

Pasteur Research Institute of Epidemiology and Microbiology, St. Petersburg, Russia

M. V Ermakova

Administration of the Federal Service of Surveillance for Protection of Consumers Rights and Human Welfare for Murmansk Region, Russia

L. S Kamynina

Centre of Hygiene and Epidemiology in Murmansk Region, Murmansk, Russia

A. G Madoyan

Administration of the Federal Service of Surveillance for Protection of Consumers Rights and Human Welfare for Leningrad Region, Russia

N. V Valdaitseva

Centre of Hygiene and Epidemiology in Leningrad Region, St. Petersburg, Russia

N. P Leonova

Administration of the Federal Service of Surveillance for Protection of Consumers Rights and Human Welfare for Novgorod Region, Russia

T. G Ivanova

Centre of Hygiene and Epidemiology in Novgorod Region, Veliky Novgorod, Russia

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Copyright (c) 2014 Bichurina M.A., Romanenkova N.I., Novikova N.A., Golitsyna L.N., Rozaeva N.R., Kanaeva O.I., Ermakova M.V., Kamynina L.S., Madoyan A.G., Valdaitseva N.V., Leonova N.P., Ivanova T.G.

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