LEVEL OF sIgA, IgG, IgA IN VAGINAL SECRETION IN WOMEN WITH CHRONIC INFLAMMATORY DISEASE OF SMALL PELVIS ORGANS

Aim. Determine levels of sIgA, IgG, IgA in vaginal secretion and saliva ofwomen of reproductive age with chronic inflammatory diseases of small pelvis organs (IDSPO) at exacerbation stage and remission period. Materials and methods. Clinical-laboratory and gynecological examination of 105 women was carried out. Based on the results obtained 3 groups were formed: patients with IDSPO at exacerbation stage; patients at remission stage; clinically healthy women. sIgA, IgG, IgA parameters were studied in vaginal secretion and saliva in women with IDSPO at exacerbation stage and remission period by radial immune diffusion in gel by Manchini method. Results. An increase of immunoglobulin level in vaginal secretion of women with IDSPO at remission period and a sharper increase of these parameters during exacerbation of the disease compared with women of the control group were detected. During analysis of sIgA, IgG, IgA levels in saliva in the same groups of women the results were obtained that give evidence that the presence of IDSPO and local immune reaction do not lead to the changes of these parameters. Conclusion. The obtained parameters on the dependence of an increase of immunoglobulin levels in vaginal secretions and the degree of intensity of the inflammatory process give basis to use them with the aim of additional diagnostics.

IgA, sIgA, IgG, vaginal secretion, inflammatory diseases of small pelvis organs