HELICOBACTER PYLORI POPULATION CHARACTERISTIC IN PATIENTS WITH DISEASES OF GASTROINTESTINAL TRACT


Cite item

Full Text

Abstract

Aim. Study Н. pylori strains circulating in St. Petersburg among patients with various gastrointestinal tract pathology as well as study of frequency of infection by Н. pylori based on serological markers data among this group of patients. Materials and methods. By using serological method 162 individuals with various chronic diseases of stomach and duodenum were examined. The presence in blood serum of IgG against Н. pylori bacterial antigen and IgG against its toxin - CagA was studied. 129 patients were examined bacteriologically, biopsy samples of stomach mucous membrane were studied. PCR in real time format was used for study of Н. pylori strains (49) and biopsy samples (36) of stomach mucous membrane. Results. The analysis performed showed that on the territory of St. Petersburg Н. pylori strains containing cagA gene predominate (81.63% of the isolated strains). Genotyping of strains by vacA showed that s1m1 genotype was more frequent (in 57.14% of cases). The fraction of CagA positive strains in patients in St. Petersburg is maximum for stomach cancer (90.8%), whereas for peptic ulcer disease and gastritis it is 64.7% and 72.2%, respectively. In patients with stomach and duodenum pathology the parameters of seropositivity for Н. pylori were significantly higher than in individuals without clinical manifestations ofН.pylori infection (86.72% against 65.09%; p<0.05). Conclusion. The data obtained on increase of fraction of CagA positive strains among Н. pylori circulating in St. Petersburg determine the importance of conducting eradication Н. pylori.

About the authors

A. B Zhebrun

Pasteur Research Institute of Epidemiology and Microbiology, St. Petersburg, Russia

A. V Svarval

Pasteur Research Institute of Epidemiology and Microbiology, St. Petersburg, Russia

O. A Balabash

Pasteur Research Institute of Epidemiology and Microbiology, St. Petersburg, Russia

R. S Ferman

Pasteur Research Institute of Epidemiology and Microbiology, St. Petersburg, Russia

References

  1. Жебрун А.Б. Инфекция H. pylori. СПб, Феникс, 2006.
  2. Жебрун А.Б., Александрова В.А., Гончарова Л.Б., Ткаченко Е.И. Диагностика, профилактика и лечение заболеваний, ассоциированных с Helicobacter pylori-инфекцией. Санкт-Петербург, 2002.
  3. Кондратьева К.Ф. Эпидемиологические аспекты болезней органов пищеварения, ассоциированных с Helicobacter pylori, в условиях многолетнего динамического наблюдения. Дисс. канд. мед. наук. Уфа-СПб, 2004.
  4. Atherton J. C., Peek R. M., Tham K. T. et al. Clinical and pathological importance of heterogeneity in vacA, the vacuolating cytotoxin gene of Helicobacter pylori. Gastroenterology. 1997, 112: 92-99.
  5. Atisook K., Kachinthorn U., Luengrojanakul P. et al. Histology of gastritis and Helicobacter pylori infection in Thailand: a nation wide study of 3776 cases. Helicobacter. 2003, 8 (2): 132141.
  6. Borch K., Jonsson K., Petersson F. et al. Prevalence of gastroduodenitis and Helicobacter pylori infection in a general population sample. Relation to symptomatology and life style. Dis. Sci. 2000, 45 (7): 1322-1329.
  7. Furuta T., Delchier J.C. Helicobacter pylori and non-malignant diseases. Helicobacter. 2009, 14 (1): 29-35.
  8. Gallo N., Zambon C., Navaglia F. et al. Helicobacter pylori infection in children and adults: a single pathogen but a different pathology. Helicobacter. 2003, 8: 21-28.
  9. Goh K.L., Chan W.K., Shiota S., Y&maoka Y. Epidemiology of Helicobacter pylori infection and public health implications. Helicobacter. 2011, 16 (l. 1): 1-9.
  10. Jafari F., Shokrzadeh L., Dabiri H. et al. vacA genotypes of Helicobacter pylori in relation to cagA status and clinical outcomes in Iranian populations. Jpn J. Infect. Dis. 2008, 61: 290293.
  11. Kim N., Park Y.S., Cho S.I. et al. Prevalence and risk factors of atrophic gastritis and intestinal metaplasia in a Korean population without significant gastroduodenal disease. Helicobacter. 2008, 13: 245-255.
  12. Michara M., Haruma K., Kamada T. et al. The role of the endoscopic findings fort he diagnosis of H. pylori infection: evaluation in a country with high prevalence of atrophic gastritis. Helicobacter. 1999, 4 (1): 40.
  13. Ohnishi N., Yuasa H., Tanaka S. et al. Transgenic expression of Helicobacter pylori CagA induces gastrointestinal and hematopoietic neoplasms in mouse. Proc. Natl. Acad. Sci. USA. 2008, 105: 1003-1008.

Supplementary files

Supplementary Files
Action
1. JATS XML
Download

Copyright (c) 2013 Zhebrun A.B., Svarval A.V., Balabash O.A., Ferman R.S.

Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.
СМИ зарегистрировано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор).
Регистрационный номер и дата принятия решения о регистрации СМИ: ПИ № ФС77-75442 от 01.04.2019 г.


This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies