Email this article CYTOKINE STATUS OF CERVICAL MUCUS IN WOMEN WITH TRANSITORY AND PERSISTENT COURSE OF PAPILLOMAVIRUS INFECTION
- Authors: Telesheva LF1, Dolgushina VF1, Abramovskikh OS1, Zotova MA1, Mezentseva EA1, Orner IY.1, Baturina IL1, Akhmatova AN1
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- Issue: Vol 89, No 4 (2012)
- Pages: 118-121
- Section: Articles
- URL: https://microbiol.crie.ru/jour/article/view/13780
- ID: 13780
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Abstract
course of papillomavirus infection (PVI). Materials and methods. Material from 122 women was
studied: 32 patients in control group, 68 patients with transitory course of PVI and 52 women with
persistent course of PVI. The presence or absence of high risk HPV DNA was confirmed by real
time PCR. High risk HPV DNA was determined in scrapes of epithelial cells of cervical canal.
Quantitative determination of cytokines (IFN-, IFN-, IL-1, receptor antagonist IL-1, IL-2,
IL-4, IL-8 and IL-10, TNF) in cervical mucus was performed by enzyme immunoassay. Results.
Transitory course of PVI was characterized by an increase of IFN- and IFN-, persistent course
of PIV - by a decrease of IFN-, IL-2 level was increased in both groups of patients with PVI.
Conclusion. The outcome of PVI is controlled by interferon component of the immunity. Because
of this during observation of patients with PVI the determination of IFN-, IFN- content in
cervical mucus is an appropriate diagnostic procedure in clinical practice for the prognosis of risk
of development of high risk PIV persistency.
About the authors
L F Telesheva
V F Dolgushina
O S Abramovskikh
M A Zotova
E A Mezentseva
I Yu Orner
I L Baturina
A N Akhmatova
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