DESTABILIZATION OF HOMEOSTASIS OF ORGANISM OF BURN PATIENTS AS A MAR KER OF SEPSIS DEVELOPMENT, ITS COMPLICATIONS AND OUTCOME

Aim. Detection in burn patients of markers of sepsis development, its complications and outcome.
Materials and methods. Sera IL-6, TNF-ƒ, IL-8, IL-1ƒ, IL-1Ra, IL-18, INF-ƒ, IL-10 and
sTREM-1 cytokine levels of burn patients at days 3 - 6 and 10 - 17 after the burn were studied.
Results. Statistically significant cytokine parameters in blood sera that already at the early stages
of the burn disease may be markers of the course severity and sepsis outcome were obtained. At
day 3 - 6 after the injury high level of IL-10 in blood sera may act as a lethal outcome marker in
burn patients, and by day 10 - 17 after the burn high level of IL-6 becomes determinative. Low
level of IL-1ƒ may serve as a marker of complicated course of sepsis in patients with favorable
outcome already at days 3 - 6 after the injury. Conclusion. Certain laboratory parameters of human
organism homeostasis destabilization may be used as markers of sepsis development, its complications
and outcome already in the initial period of burn disease in severe thermal injuries.

burns, sepsis, cytokines