Email this article PREVALENCE OF MUTATIONS RESPONSIBLE FOR RESISTANCE TO ANTIRETROVIRAL PREPARATIONSAMONG HIV-1 VARIANTS CIRCULATING IN NOVOSIBIRSK REGION
- Authors: Gashnikova NM1, Bogachev VV1, Baryshev PB1, Meshcheryakova Y.V1, Savochkina EN1, Chernousova NY.1, Gashnikova NM2, Bogachev VV2, Baryshev PB2, Mescheryakova Y.V3, Savochkina EN3, Chernousova NY.3
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Affiliations:
- State Scientific Centre of Virology and Biotechnology Vector
- Novosibirsk Regional Centre of Prophylaxis andControl of AIDS and Infectious Diseases, Koltsovo, Novosibirsk region, Russia
- Issue: Vol 89, No 6 (2012)
- Pages: 56-60
- Section: Articles
- URL: https://microbiol.crie.ru/jour/article/view/13722
- ID: 13722
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Abstract
genome emerging in response to antiretroviral therapy isolated from HIV-infected individuals of Novosibirsk
region in 2010, 2011. Materials and methods. Detection of mutations in HIV-1 genome responsible for the
resistance to antiretroviral preparations (ARVP) was carried out by determination of pol gene nucleotide
sequence and subsequent analysis of the data obtained by program HIVdb: Genotypic Resistance Interpretation
Algorithm. Results. HIV-1 resistance mutations to antiretroviral preparations were detected in 23.6% of the
total number of the studied samples. The most prevalent mutations are those conditioning resistance to
nucleoside and non-nucleoside reverse transcriptase inhibitors (M184V, Y181C and K103N). In studies of
HIV-1 isolated from 4 patients who had not received antiretroviral therapy (ARVT) transmission of HIV-1
resistant to various groups of preparations was detected. Conclusion. The detected facts of ARVP resistant
HIV-1 circulation among patients who had not received ARVT and the data obtained on the mutations
emerging in response to therapy underline the relevance of administration of HIV-1 resistance profile study
during both decrease of ARVT effectiveness and primary administration of therapy to HIV infected patients.
About the authors
N M Gashnikova
V V Bogachev
P B Baryshev
Yu V Meshcheryakova
E N Savochkina
N Ya Chernousova
N M Gashnikova
State Scientific Centre of Virology and Biotechnology VectorState Scientific Centre of Virology and Biotechnology Vector
V V Bogachev
State Scientific Centre of Virology and Biotechnology VectorState Scientific Centre of Virology and Biotechnology Vector
P B Baryshev
State Scientific Centre of Virology and Biotechnology VectorState Scientific Centre of Virology and Biotechnology Vector
Yu V Mescheryakova
Novosibirsk Regional Centre of Prophylaxis andControl of AIDS and Infectious Diseases, Koltsovo, Novosibirsk region, RussiaNovosibirsk Regional Centre of Prophylaxis andControl of AIDS and Infectious Diseases, Koltsovo, Novosibirsk region, Russia
E N Savochkina
Novosibirsk Regional Centre of Prophylaxis andControl of AIDS and Infectious Diseases, Koltsovo, Novosibirsk region, RussiaNovosibirsk Regional Centre of Prophylaxis andControl of AIDS and Infectious Diseases, Koltsovo, Novosibirsk region, Russia
N Ya Chernousova
Novosibirsk Regional Centre of Prophylaxis andControl of AIDS and Infectious Diseases, Koltsovo, Novosibirsk region, RussiaNovosibirsk Regional Centre of Prophylaxis andControl of AIDS and Infectious Diseases, Koltsovo, Novosibirsk region, Russia
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