MOLECULAR-BIOLOGICAL AND ANTIGENIC FEATURES OF H5N1 SUBTYPE HIGHLY PATHOGENIC INFLUENZA VIRUS STRAINS ISOLATED IN SOUTHERN SIBERIA IN 2005-2009


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Abstract

Aim. Study of molecular-biological and antigenic features of H5N1 subtype virus strains isolated in southern Siberia in 2005-2009. Materials and methods. Study was performed by using standard procedures according to WHO recommendations. Results. Hemagglutinin gene of H5N1 subtype virus strain isolated in Siberia belongs to 2 genetical lineages: 2.2 and 2.3.2. Strains of these 2 lineages have antigenic differences. All of the strains are highly pathogenic for chicken and white mice. Conclusion. H5N1 subtype highly pathogenic influenza virus variants of 2 different antigenic lineages that have antigenic differences circulated in Siberia in 2005-2009. A possible role of antigenic drift in evolution of H5N1 subtype influenza virus is discussed.

About the authors

K. A Sharshov

State Scientific Center of Virology and Biotechnology Vector, Koltsovo, Novosibirsk Region, Russia

A. G Durymanov

State Scientific Center of Virology and Biotechnology Vector, Koltsovo, Novosibirsk Region, Russia

A. A Romanovskaya

State Scientific Center of Virology and Biotechnology Vector, Koltsovo, Novosibirsk Region, Russia

A. V Zaikovskaya

State Scientific Center of Virology and Biotechnology Vector, Koltsovo, Novosibirsk Region, Russia

V. Yu Marchenko

State Scientific Center of Virology and Biotechnology Vector, Koltsovo, Novosibirsk Region, Russia

N. Yu Silko

State Scientific Center of Virology and Biotechnology Vector, Koltsovo, Novosibirsk Region, Russia

F. A Ilinykh

State Scientific Center of Virology and Biotechnology Vector, Koltsovo, Novosibirsk Region, Russia

I. M Susloparov

State Scientific Center of Virology and Biotechnology Vector, Koltsovo, Novosibirsk Region, Russia

A. Yu Alekseev

State Scientific Center of Virology and Biotechnology Vector, Koltsovo, Novosibirsk Region, Russia

A. M Shestopalov

State Scientific Center of Virology and Biotechnology Vector, Koltsovo, Novosibirsk Region, Russia

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Copyright (c) 2011 Sharshov K.A., Durymanov A.G., Romanovskaya A.A., Zaikovskaya A.V., Marchenko V.Y., Silko N.Y., Ilinykh F.A., Susloparov I.M., Alekseev A.Y., Shestopalov A.M.

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