ANTIBACTERIAL ACTIVITY OF NANOSTRUCTURED SILVER GEL

Aim. Evaluation of antimicrobial activity of L-cysteine silver gel against various species of pathogenic and opportunistic microorganisms. Materials and methods. Antibacterial activity of L-cysteine silver gel with silver concentration from 1.28x10 - 3 to 3.75x10 - 3 mole/l was studied by using agar diffusion test. Reparation processes were determined experimentally in 102 male Wistar rats (150 g) by forming under ether anesthesia a 225 mm 2 skin wound on the back surface of the body and by introducing virulent strain Staphylococcus aureus 236 24-hour suspension (10 6 CFU/ml) inside the wound. The rat wounds were treated with L-cysteine silver gel once per day for one week and proliferation processes were studied on day 7, 14 and 21. Results. Antibacterial activity of L-cysteine silver gel was detected against test strains: S.aureus ATCC 25923; Bacillus subtilis 537; Escherichia coli ATCC 25922; Shigella sonnei 1908; Pseudomonas aeruginosa ATCC 27853; Salmonella typhimurium 5715 and Candida albicans ATCC 885-653. Mean period of wound healing was reduced by 3 days when L-cysteine silver gel was used, index of healing acceleration was approximately 20%. Conclusion. L-cysteine silver gel has antibacterial and wound healing properties, it can be used for the creation of new medical preparations.

L-cysteine silver gel, antimicrobial acti- vity, reparative properties