Email this article PREVALENCE OF HELICOBATER PYLORI INFECTION AMONG POPULATION OF NORTHWESTERN FEDERAL DISTRICT OF RUSSIAN FEDERATION
- Authors: Svarval A.V1, Ferman R.S1, Zhebrun A.B1
-
Affiliations:
- Pasteur Research Institute of Epidemiology and Microbiology, St.Petersburg, Russia
- Issue: Vol 88, No 4 (2011)
- Pages: 84-88
- Section: Articles
- URL: https://microbiol.crie.ru/jour/article/view/13553
- ID: 13553
Cite item
Full Text
Abstract
Aim. Studies of Helicobater pylori infection rate among population of North-western federal district including St.Petersburg in 2007 - 2009. Materials and methods. 1021 individuals with various digestive tract pathologies as well as healthy individuals and blood donors were examined. 378 children and adolescents up to 19 years of age, and 643 adults 20 - 80 years of age were among the examined individuals. IgG to H.pylori complex antigen and IgG to its CagA toxin were determined in blood sera. Results. Infection rate among children and adolescents was 40.48%, CagA positive strain infection rate - 34.92%. Among adults these parameters were 63.61% and 49.61%, respectively. During the 3 year study a tendency of CagA positive strain rate increase was noted among children and adolescents. Prevalence of H.pylori infection in subjectively healthy individuals, intestine oncology disease and gastric cancer patients was 55.1%, 67.16% and 83.33%, respectively. Conclusion. High rate of infection and CagA positive strain prevalence among children and adolescents can be considered as a possible factor of gastritis and ulcer rate increase in these age groups.
About the authors
A. V Svarval
Pasteur Research Institute of Epidemiology and Microbiology, St.Petersburg, Russia
R. S Ferman
Pasteur Research Institute of Epidemiology and Microbiology, St.Petersburg, Russia
A. B Zhebrun
Pasteur Research Institute of Epidemiology and Microbiology, St.Petersburg, Russia
References
- Баранская Е.К. Язвенная болезнь и инфекция H. pylori. Бол. орг. пищ. 2000, 2 (1): 8-14.
- Жебрун А.Б. Инфекция H. pylori. СПб., Феникс, 2006.
- Blaser M.J., Atherton J.C. Helicobacter pylori persistence: biology and disease. J. Clin. Invest. 2004, 113 (3; 1): 321-333.
- Blaser M.J. Hypothesis: The changing relationships of Helicobacter pylori and humans: implications for health and disease. J. Infect. Dis. 1999, 179 (6): 1523-1530.
- Frenck R., Clemens J. Helicobacter in the developing world. Microb. Infect. 2003, 5(8): 705-713.
- Graham D. Can therapy even be denied for Helicobacter pylori infection? Gastroenterology. 1997, 113 (6): S113-117.
- Lambert J., Lin S. Prevalence disease correlates H.pylori. In: Helicobacter pylori. Basic mechanisms to clinical cure. E.Hunt, G.Tytgat (ed.). Dordrecht/Boston/London, Kluwer Acad. Publ., 1994, р. 169-179.
- Marshall B., Warren J. Unidentified curved bacilli in the stomach of patients with gastritis and peptic ulceration. Lancet. 1984, 1: 1311-1315.
- Parsonnet J., Friedman G., Oretreich N., Vogelman H. Risk for gastric cancer in people with CagA positive or CagA negative H. pylori infection. Gut. 1997, 40: 297-301.
- Rothenbacher D., Brenner H. Burden of H. pylori and diseases in developed countries; recent developments and future implications. Microb. Infect. 2003, 5(80): 693-703.
Supplementary files
