Email this article PROGNOSTIC VALUE OF LIPOPOLYSACCHARIDE AND LIPOPOLYSACCHARIDE-BINDING PROTEIN SERUM LEVELS IN CANCER PATIENTS WITH SEPSIS
- Authors: Anisimova N.Y.1, Gromova E.G1, Kuznetsova L.S1, Kiselevsky M.V1
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Affiliations:
- Blokhin Russian Oncological Scientific Center, Moscow, Russia
- Issue: Vol 88, No 2 (2011)
- Pages: 82-84
- Section: Articles
- URL: https://microbiol.crie.ru/jour/article/view/13514
- ID: 13514
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Abstract
Aim. Analysis of LPS and LPS-binding protein (LBP) serum levels and prognostic value evaluation in cancer patients with sepsis. Materials and methods. Blood samples of 17 healthy donors and 46 cancer patients with sepsis were analyzed by using «Hycult biotechnology» kits (the Netherlands). Results. Serum LPS level in cancer patients with sepsis was increased significantly. A substantial decrease of LBP level was detected in blood samples of deceased patients. Conclusion. Dynamic increase of LPS serum level and decrease of LPS-binding protein serum level in cancer patients should be considered as an unfavo- rable factor for sepsis.
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ПРОГНОСТИЧЕСКОЕ ЗНАЧЕНИЕ СЫВОРОТОЧНОГО УРОВНЯ ЛИПОПОЛИСАХАРИДА И ЛИПОПОЛИСАХАРИД-СВЯЗЫВАЮЩЕГО БЕЛКА У ОНКОЛОГИЧЕСКИХ БОЛЬНЫХ С СЕПСИСОМ×
About the authors
N. Yu Anisimova
Blokhin Russian Oncological Scientific Center, Moscow, Russia
E. G Gromova
Blokhin Russian Oncological Scientific Center, Moscow, Russia
L. S Kuznetsova
Blokhin Russian Oncological Scientific Center, Moscow, Russia
M. V Kiselevsky
Blokhin Russian Oncological Scientific Center, Moscow, Russia
References
- Angus D.C., Linde-Zwirble W.T., Lidicker J. et al. Epidemiology of severe sepsis in the United States: analysis of incidence, outcome, and associated costs of care. Crit.Care Med. 2001, 29: 1303–1310.
- Balzan S., Quadros C. A., Cleva R. B. et al. Bacterial translocation: Overview of mechanisms and clinical impact. J. Gastroenterol. Hepatol. 2007, 22(4): 464–471.
- Claudi S.M. Nijhuis O., Vellenga E. et al. Lipopolysaccharide-binding protein: a possible diagnostic marker for Gram-negative bacteremia in neutropenic cancer patients. Int. Care Med. 2003, 29(12) : 2157–2161.
- Deitch E.A., Bridges R.M. Effect of stress and trauma on bacterial translocation from the gut. J. Surg Res. 1987, 42(5): 536–542.
- Myc A., Buck J., Gonin J. et al. The level of lipopolysaccharide-binding protein is significantly increased in plasma in patients with the systemic inflammatory response syndrome. Clin. Diagn. Lab. Immunol. 1997, 4: 113–116.
- Takeshita S., Tsujimoto H., Kawase H. et al. Increased levels of lipopolysaccharide binding protein in plasma in children with kawasaki disease. Ibid. 2002, 9(1): 205–206.
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