Email this article MODIFICATION OF INFRASTRUCTURE OF CANDIDA ALBICANS UNDER THE INFLUENCE OF ASSOCIATIVE MICROBIOTA EXOMETABOLITES
- Authors: Timokhina T.K.1, Nikolenko M.V1, Varnitsyna V.V1, Perunova N.B2, Bukharin O.V2
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Affiliations:
- Tyumen State Medical Academy, Orenburg, Russia
- Institute of Cellular and Intracellular Symbiosis, Orenburg, Russia
- Issue: Vol 88, No 3 (2011)
- Pages: 67-70
- Section: Articles
- Submitted: 09.06.2023
- Published: 15.06.2011
- URL: https://microbiol.crie.ru/jour/article/view/13497
- ID: 13497
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Abstract
Aim. Evaluation of the influence of bacterial microbiota exometabolites on temporal organization of biological features of Candida albicans . Materials and methods. Experiments were carried out on the model of C.albicans 24433 ATCC for 24 hours with 4 hour intervals. Biorythms of proliferative, phospholipase and adhesive activity of fungi were studied. Influence of exometabolites of Staphylococcus aureus 25923 АТСС, Escherichia coli 35218 АТСС, Pseudomonas aeruginosa 27853 АТСС on biological properties of C.albicans were examined. The results were statistically analyzed by using Student’s t-test. Results. Circadian biological rhythms were detected for all investigated parameters of C.albicans 24433 АТСС. In the presence of exometabolites of S.аureus and P.аeruginosa , rhythm profile and amplitude oscillation of the fungi changes, and phase synchronism is disrupted. Under the influence of exometabolites of Gram-negative microbiota a marked desynchrony of fungi adhesive activity was observed. Conclusion. The results obtained confirm the key role of microorganisms in the formation and regulation of pathogenic microsymbiocenosis, and determine the necessity to study mechanisms of symbiotic interaction of bacteria and fungi.
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МОДИФИКАЦИЯ ИНФРАСТРУКТУРЫ CANDIDA ALBICANS ПОД ВЛИЯНИЕМ ЭКЗОМЕТАБОЛИТОВ АССОЦИАТИВНОЙ МИКРОБИОТЫ×
About the authors
T. Kh Timokhina
Tyumen State Medical Academy, Orenburg, Russia
M. V Nikolenko
Tyumen State Medical Academy, Orenburg, Russia
V. V Varnitsyna
Tyumen State Medical Academy, Orenburg, Russia
N. B Perunova
Institute of Cellular and Intracellular Symbiosis, Orenburg, Russia
O. V Bukharin
Institute of Cellular and Intracellular Symbiosis, Orenburg, Russia
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