PANDEMIC INFLUENZA VIRUS A (H1N1) IN AMUR REGION IN AUTUMN 2009


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Abstract

Aim. Isolation and study of molecular genetic characteristics of pandemic influenza virus A (H1N1) circulated in Amur region in autumn 2009 as well as testing of serum samples taken from citizens of this region during November-December 2009 in order to measure levels of antibodies to socially significant serotypes of influenza A virus. Materials and methods. Strain of pandemic influenza virus A/Blagoveschensk/01/2009 (H1N1) was isolated on MDCK cell culture and nucleotide sequences of all eight segments of viral genome were determined. Five hundred seventy-six serum samples taken in Amur region in autumn 2009 were tested by hemagglutination inhibition assay. Results. Nucleotide sequence of A/ Blagovechensk/01/2009 (H1N1) strain was 99.7% identical to reference influenza virus strain A/California/04/2009. Diagnostically significant titers of antibodies to pandemic influenza virus were observed in 46.3% of persons younger 30 years old and in 20.1% older persons. Antibodies to seasonal influenza virus H1N1 and H3N2 were detected in 39.5 and 29.8% of persons respectively. Conclusion. Final seroepidemiological picture of distribution of pandemic virus in Amur region matches with the one for seasonal influenza virus A (H1N1): >60% of seropositive persons were registered in age group <18 years old, and this proportion increases with increasing age.

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ПАНДЕМИЧЕСКИЙ ВИРУС ГРИППА A (H1N1) В АМУРСКОЙ ОБЛАСТИ ОСЕНЬЮ 2009 Г
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About the authors

A. A Romanovskaya

State Scientific Center of Virology and Bio- technology «Vector», Koltsovo, Novosibirsk region

T. N Ilyicheva

State Scientific Center of Virology and Bio- technology «Vector», Koltsovo, Novosibirsk region

A. G Durymanov

State Scientific Center of Virology and Bio- technology «Vector», Koltsovo, Novosibirsk region

M. B Ignashkina

State Scientific Center of Virology and Bio- technology «Vector», Koltsovo, Novosibirsk region

K. A Sharshov

State Scientific Center of Virology and Bio- technology «Vector», Koltsovo, Novosibirsk region

I. M Susloparov

State Scientific Center of Virology and Bio- technology «Vector», Koltsovo, Novosibirsk region

E. M Malkova

State Scientific Center of Virology and Bio- technology «Vector», Koltsovo, Novosibirsk region

E. A Stavsky

State Scientific Center of Virology and Bio- technology «Vector», Koltsovo, Novosibirsk region

A. M Shestopalov

State Scientific Center of Virology and Bio- technology «Vector», Koltsovo, Novosibirsk region

V. T Smirnov

Administration of Federal Service for Surveillance for Consumer Rights and Human Welfare in Amur region

N. N Zhukova

Administration of Federal Service for Surveillance for Consumer Rights and Human Welfare in Amur region

I. I Pavlova

Administration of Federal Service for Surveillance for Consumer Rights and Human Welfare in Amur region

T. Yu Nekhryuk

Center of Hygiene and Epidemiology in Amur region, Blagoveschensk, Russia

T. P Panamareva

Center of Hygiene and Epidemiology in Amur region, Blagoveschensk, Russia

I. G Drozdov

State Scientific Center of Virology and Bio- technology «Vector», Koltsovo, Novosibirsk region

References

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Copyright (c) 2011 Romanovskaya A.A., Ilyicheva T.N., Durymanov A.G., Ignashkina M.B., Sharshov K.A., Susloparov I.M., Malkova E.M., Stavsky E.A., Shestopalov A.M., Smirnov V.T., Zhukova N.N., Pavlova I.I., Nekhryuk T.Y., Panamareva T.P., Drozdov I.G.

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