Email this article EFFECT OF ENTEROBACTER CLOACAE THERMOLABILE ENTEROTOXIN ON IMMUNE SYSTEM OF MICE
- Authors: Akhtarieva A.A1, Dolgushin I.I2, Gabidullin Z.G1, Gabidullin Y.Z1, Kamalova A.A1, Akhmadeev R.M1
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Affiliations:
- Bashkir State Medical University, Ufa
- Chelyabinsk State Medical Academy, Russia
- Issue: Vol 86, No 6 (2009)
- Pages: 98-104
- Section: Articles
- Submitted: 09.06.2023
- Published: 15.12.2009
- URL: https://microbiol.crie.ru/jour/article/view/13382
- ID: 13382
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Abstract
Aim. To study the effect of Enterobacter cloacae thermolabile enterotoxin (LT-enterotoxin) on different arms of immune system of mice. Materials and methods. Proprietary clinical strain E.cloacae 258 was used and intraperitoneal inoculation of outbred white mice with LT-enterotoxin-producing E.cloacae comprised experimental model. Phagocytic and lysosomal activity of peritoneal macrophages as well as level of APC to sheep erythrocytes were measured, spontaneous and induced NBT tests were also performed. Results. Pleiotropic immunotoxic effect of LT-enterotoxin of studied bacteria was established, which characterized by suppres- sion of antigen-presenting and antigen-processing functions of macrophages, stimulation of mitotic activity of lymphocytes, decrease of activity of hexose monophosphate shunt enzymes in peritoneal macrophages as well as abnormalities in formation of specific B-lymphocytes. Conclusion. Obtained data allowed to reveal separate steps in pathogenesis of infectious process caused by LT-enterotoxinproducing bacteria from Enterobacter genus.
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ВЛИЯНИЕ ТЕРМОЛАБИЛЬНОГО ЭНТЕРОТОКСИНА ENTEROBACTER CLOACAE НА ИММУННУЮ СИСТЕМУ МЫШЕЙ×
About the authors
A. A Akhtarieva
Bashkir State Medical University, Ufa
I. I Dolgushin
Chelyabinsk State Medical Academy, Russia
Z. G Gabidullin
Bashkir State Medical University, Ufa
Yu. Z Gabidullin
Bashkir State Medical University, Ufa
A. A Kamalova
Bashkir State Medical University, Ufa
R. M Akhmadeev
Bashkir State Medical University, Ufa
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