TOLL-LIKE RECEPTORS RECOGNIZING LIGANDS OF HERPESVIRUS


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Abstract

Innate immunity is the first line of host defense against infection including those caused by herpesviruses. Toll-like receptors (TLRs) are the main pathogen-recognizing receptors. TLR2 binds to glycoproteins of herpesvirus virion; intracellular TLR9 recognizes nonmethylated CpG repeats of herpesvirus' DNA, which lead to activation of receptor signaling pathways and synthesis of proinflammatory cytokines, chemokines, antimicrobial peptides and other molecules, which participate in induction of innate immunity mechanisms. Many viruses (measles virus, cytomegalovirus etc.) activate expression of TLRs for more effective replication of the virus in cells.

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TOLL-ПОДОБНЫЕ РЕЦЕПТОРЫ, РАСПОЗНАЮЩИЕ ЛИГАНДЫ ВИРУСА ГЕРПЕСА
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About the authors

O. A Gankovskaya

Mechnikov Research Institute of Vaccines and Sera; Russian State Medical University, Moscow, Russia

L. V Gankovskaya

Mechnikov Research Institute of Vaccines and Sera; Russian State Medical University, Moscow, Russia

O. Yu Somova

Mechnikov Research Institute of Vaccines and Sera; Russian State Medical University, Moscow, Russia

V. V Zverev

Mechnikov Research Institute of Vaccines and Sera; Russian State Medical University, Moscow, Russia

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Copyright (c) 2009 Gankovskaya O.A., Gankovskaya L.V., Somova O.Y., Zverev V.V.

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