EPIDEMIC PROCESS OF GONORRHEA IN MODERN WORLD


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Abstract

Gonorrhea in spite of its fully elucidated etiopathogenesis and available drugs for etiotropic therapy belongs to infections which are not controlled by vaccination due to absence of immunity formation. Analysis of scientific publication, statistical materials and WHO’s data showed that epidemic process of gonorrhea infection depends mainly from people’s behaviour, first of all, sexual. Modern epidemic process of gonorrhea infection consists from irregular increases and decreases of incidence due to various reasons. Reasons for increases of incidence appear to be simultaneous action of a range of biologic and anthropogenic factors. First reason — rapid increase of resistance of gonococci to widely used antibacterial preparations as well as synergy of pathogenic effects between HIV and gonococci; anthropogenic — wars, increase of highrisk groups due to urbanization, use of oral contraceptives, rise of prostitution, migration, inadequate access to medical care, poverty, intensification of intercourses (including heteroand homosexual) between people, as well as demographic changes — increase of proportion of young people in population structure. Same but reciprocal factors lead to decrease of morbidity. Of them, the following were considered as most important: mass implementation of new effective antimicrobial drug as well as intensification of sanitary education, availability of early diagnostics and treatment, increase of material and cultural standards of life, decrease in number of persons belonging to high risk groups. Yet, capabilities of modern science expressed only in continuous development of new antibacterial drugs active against circulating population of gonococci, which is resistant to previously used drug.

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ЭПИДЕМИЧЕСКИЙ ПРОЦЕСС ГОНОРЕИ В СОВРЕМЕННОМ МИРЕ
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About the authors

N. N Kostyukova

Gamaleya Research Institute of Epidemiology and Microbiology, Moscow, Russia

V. A Bekhal

Gamaleya Research Institute of Epidemiology and Microbiology, Moscow, Russia

References

  1. Бехало В.А., Костюкова Н.Н. Новый взгляд на развитие гонококкового инфекционного процесса. Клин. дерматол. венерол. 2007, 6: 4—8.
  2. Верещагин В.А. Молекулярное типирование клинических штаммов Neisseria honorrhoeae. Автореф. дисс. канд. биол. наук. М., 2006.
  3. Кисина В.И., Забиров К.И. Урогенитальные инфекции у женщин. Клиника, диагностика, лечение. М., Мединформ, 2005.
  4. Кобенко Э.Г., Герасимова Н.М., Евстигнеева Н.П. и др. Эффективность отечественных ПЦР-систем «АмплинСенс-Гонорея» и «Гонопол» в сравнении с традиционными методами лабораторной диагностики. Рос. журн. кож. венер. бол. 2005, 1: 53—56.
  5. Колиева Т.Л., Кисина В.И. Эпидемиология гонококковой инфекции и клиническое значение устойчивости Neisseria gonorrhoeae к фторхинолонам. Инфекц. передав. полов. путем. 2003, 2: 4—14.
  6. Костюкова Н.Н, Бехало В.А. Молекулярно-биологические основы патогенности гонококка и особенности иммунного ответа. Журн. микробиол. 2006, 1: 105-112.
  7. Кубанова А.А., Аковбян В.А. Инфекции, возбудители которых передаются половым путем. В: В.И.Покровский, Г.Г.Онищенко, Б.Л.Черкасский (р ед.). Эволюция инфекционных болезней в России в ХХ веке. М., Медицина, 2003, с. 539—551.
  8. Официальная информация Федерального Центра гигиены и эпидемиологии Федеральной службы Роспот ребна дзора. Эпидемиол. вакцинопроф. 2008, 1: 52—55.
  9. Черкасский Б.Л. Общая эпидемиология. М., Медицина, 2003.
  10. Чураков А.С. Современные аспекты эпидемиологии, клиники и лечения гонококковой инфекции у мужчин. Автореф. дисс.канд. мед наук, Екатеринбург, 2006.
  11. Alary M. Gonorrhea: epidemiology and control strategies. Can. J. Hum. Sex. 1997, 6 (2): 1—10.
  12. Anonymous. Increase in unsafe sex and rectal gonorrhea among men who have sex with men — San-Francisco, California, 1994—1997. MMWR. 1999, 48: 45—48.
  13. Bash M.C. Gonorrhea update. Curr. Infect. Dis. Rep. 2004, 6: 129—134.
  14. Bredlund T., Fredlund H., Gieske J. Epidemiology of reemergence of gonorrhea in Sweden. Sex. Transmitt. Dis. 2001, 28 (2): 111—114.
  15. Broutet N. World epidemiology of sexually transmitted infections. WHO, Geneva, Training course in reproduc- tive health/ sexual health, Marth, 2006.
  16. Brunham R.C., Plummer F.A. A general model of sexually transmitted disease epidemiology and its im- plications for control. Med. Clin. North. Am. 1990, 74: 1339—1342.
  17. Dallabetta G., Hook E.W.IIId. Gonococcal infections. Infect. Dis. Clin. North. Am. 1987, 1: 25.
  18. Division of STD prevention. Sexually transmitted disea- se surveillance, 1992. US Dept. of Health and Human Services, Atlanta: Centers for Disease Control and Prevention, 1993.
  19. Douglas J.M. STD in US, 2003: an update on national epidemiology and considerations for national STD control. Centers for Disease Control and Prevention, 2004.
  20. Edwards J.L., Apicella M.A. The molecular mechanisms by Neisseria gonorrhoeae to initiate infection, differ between men and women. Clin. Microbiol. Rev. 2004, 17 (4): 265—281.
  21. Garnett G.P., Anderson R.M. Contact tracing and the estimation of sexual mixing patterns: the epidemiology of gonococcal infection. Sex. Trans. Dis. 1993, 20: 181.
  22. Georgala S., Schulperis K., Georgala K., Karikis G. Gonorrhea control programme in Athens., 1974—1998. Sex. Trans. Infect. 2001, 77: 458—460.
  23. Gerbase A.S. Global prevalence and incidence estimated of selected curable STDs. Ibid. 1998, 74 (1): S12—S16.
  24. Gray-Owen S.D., Blumberg R.S. CEACAM1: contact-dependent control of immunity. Nature Rev. Immunol. 2006, 443—446.
  25. Green M.S., Anis E., Gandacu D., Groffo I. Israel: an international phenomenon? Sex.Trans.Infect. 2003, 79 (2): 116—118.
  26. Hiltunen-Back E. Epidemiology of syphilis, gonorrhea and Chlamydia trachomatis infection in Finland in 1999. Academic dissertation, Helsinki, 2002.
  27. Holmes K.K., Johnson D.W., Trostale H.J. An estimation of the risk of men acquiring gonorrhea by sexual contact with infected females. Am.J. Epidemiol. 1970, 91: 170.
  28. Holmes K.K. Human ecology and behavior and sexually transmitted infections. Proc. Natl. Acad. Sci. USA. 1994, 91: 2448—2455.
  29. Hook E.W.IIId, Handsfield H.H. Gonococal infection in the adult. In: K.K.Holmes et al. (ed.). Sexually transmited diseases. WC, 1999, p. 451—466.
  30. Kolader M.-E., Dukers N.H.T.M.,van der Bij F.R et al. Molecular epidemiology of Neisseria gonorrhoeae in Amsterdam, the Netherlands, shows distinct hetero- sexual and homosexual networks. J.Clin. Microbiol. 2006, 44 (8): 89—97.
  31. Levine W.C., Pope V. et al. Increase of endocervical CD4 lymphocytes among women with nonulcervative sexually transmitted disease. J. Infect. Dis. 1998, 7: 167.
  32. Martin J.M., Ison C.A. detection of mixed infection of Neisseria gonorrhoeae. Sex. Transm. Infect. 2003, 79 (1): 56—58.
  33. McClelland R.S., Lavreys L., Kalingama C. et al. Contribution of HIV-1 infection to acquisition of sexually transmitted disease: a 10-year prospective study. J. Infect. Dis. 2005, 191 (3): 333—338.
  34. McCormack W.M. Clinical spectrum of infection with Neisseria gonorrhoeae. Sex. Trans. Dis. 1981, 8 (4): 305—307.
  35. Mulhall B.P. Sex and travel: studies of sexual behavior, disease and health promotion in international travelers — a global view. Int. J. STD-AIDS. 1996, 7: 455—465.
  36. Ram S., Rice P.A. Gonococcal infections. In: J.Fletcher (ed.). Infectious diseases of women. USA, 2001, p. 435—447.
  37. Risley C.L., Ward H., Choudhury B. et al. Geographical and demographic clustering of gonorrhea in London. Sex. Trans. Infect. 2007, 83: 481—487.
  38. Ross J.D., Tariq A., Ghanem M., Gulleran G. Reducing the risk of gonorrhea in black Caribbean men: can we identify risk factors? Ibid. 2003, 79 (2): 119—123.
  39. Stigum H., Flack W., Magnus P. The core-group revis- ited: the effect of partner mixing and migration on the spread of gonorrhea, Chlamydia and HIV. Match. Biosci. 1994, 120: 1.
  40. Sub-regional variations in the epidemiology of Neisseria gonorrhoeae in a large urban region of Alberta, Canada: results from spatial analyses using routinely collected data. Can. Comm. Dis. Rep. 2006, 32 (4): 1—10.
  41. Tapsall J. Antimicrobial resistance in Neisseria gonor- rhoeae. WHO Collaborating Center for STD and HIV, WHO, Geneva, 2001.
  42. Trends in reportable sexually transmitted diseases in the United States, 2006. National surveillance data for Chlamydia, gonorrhea and syphilis. Centers for Disease Control and Prevention, 2007.
  43. Turner C.F., Rogers S.M. et al. Untreated gonococcal and Chlamydia infection in a probability sample of adults. JAMA. 2002, 287: 726—733.
  44. Ward H., Ison C.A., Day S.E. et al. A prospective social and molecular investigation of gonococcal transmission. Lancet. 2000, 356 (9244): 1812—1817.

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