Email this article STUDY OF EXPRESSION OF TLR9, NF-κB, TNFα GENES IN CELLS OF CERVICAL CANAL MUCOSA IN PREGNANT WOMEN WITH HERPESVIRUS INFECTION
- Authors: Gankovskaya O.V1,2, Bakhareva I.V1,2, Gankovskaya L.V1,2, Somova O.Y.1,2, Zverev V.V1,2
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Affiliations:
- Mechnikov Research Institute of Vaccines and Sera
- Russian State Medical University, Moscow, Russia
- Issue: Vol 86, No 2 (2009)
- Pages: 61-64
- Section: Articles
- URL: https://microbiol.crie.ru/jour/article/view/13288
- ID: 13288
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Abstract
Aim. To study changes in expression of TLR9, NFκB, TNFα genes in cervical canal mucosa in pregnant women with herpesvirus infection. Materials and methods. Using previously developed real-time polymerase chain reaction assays, levels of expression of genes, which corresponding proteins play important role in TLR9-dependent signaling pathway, was quantified. Results. Two-fold, 4.4-fold, and 3-fold rise in expression of TLR9, NF-κB, and TNFα genes respectively was revealed in pregnant women with herpesvirus infection compared to women with physiologically occurring pregnancy. Conclusion. Obtained results demonstrated the activation of TLR-mediated mechanisms of innate immunity on the level of cervical canal mucosa during pregnancy complicated by viral infection.
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ИССЛЕДОВАНИЕ ЭКСПРЕССИИ ГЕНОВ TLR9, NF-κB, ФНОα В КЛЕТКАХ СЛИЗИСТОЙ ЦЕРВИКАЛЬНОГО КАНАЛА БЕРЕМЕННЫХ С ГЕРПЕСВИРУСНОЙ ИНФЕКЦИЕЙ×
About the authors
O. V Gankovskaya
Mechnikov Research Institute of Vaccines and Sera; Russian State Medical University, Moscow, Russia
I. V Bakhareva
Mechnikov Research Institute of Vaccines and Sera; Russian State Medical University, Moscow, Russia
L. V Gankovskaya
Mechnikov Research Institute of Vaccines and Sera; Russian State Medical University, Moscow, Russia
O. Yu Somova
Mechnikov Research Institute of Vaccines and Sera; Russian State Medical University, Moscow, Russia
V. V Zverev
Mechnikov Research Institute of Vaccines and Sera; Russian State Medical University, Moscow, Russia
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