DISTRIBUTION OF SPECIFIC IgG SUBCLASSES IN PATIENTS WITH PERTUSSIS AND IN HEALTHY PERSONS


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Abstract

Aim. To assess level of IgG1, IgG2, IgG3, and IgG4 to complex of antigens of Bordetella pertussis in patients with whooping cough and healthy children and adults. Materials and methods. Levels of anti-pertussis IgG subclasses in sera of patients with pertussis and healthy children and adults were measured with solid phase immunoenzyme assay using peroxidase-conjugated monoclonal antibodies to human IgG1, IgG2, IgG3, and IgG4. Results. In patients with pertussis, IgG1-IgG3-IgG2-IgG4 type of distribution of subclasses with predominance of IgG1 and IgG3 was revealed. In healthy children and adults the character type of subclasses distribution was IgG1-IgG2-IgG4 with absent or low level of IgG3. Conclusion. Detection of specific IgG3 mainly in patients with pertussis allows to consider them as a reliable serological sign of pertussis infection.

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РАСПРЕДЕЛЕНИЕ ПОДКЛАССОВ СПЕЦИФИЧЕСКИХ IgG У БОЛЬНЫХ КОКЛЮШЕМ И ЗДОРОВЫХ ЛЮДЕЙ
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About the authors

E. M Zaytsev

Mechnikov Research Institute of Vaccines and Sera; Gabrichevsky Moscow Research Institute of Epidemiology and Microbiology; Clinical Hospital for Infectious Diseases No. 1; Outpatient Clinic No.1 of Russian Academy of Sciences, Moscow, Russia

I. K Mazurova

Mechnikov Research Institute of Vaccines and Sera; Gabrichevsky Moscow Research Institute of Epidemiology and Microbiology; Clinical Hospital for Infectious Diseases No. 1; Outpatient Clinic No.1 of Russian Academy of Sciences, Moscow, Russia

M. S Petrova

Mechnikov Research Institute of Vaccines and Sera; Gabrichevsky Moscow Research Institute of Epidemiology and Microbiology; Clinical Hospital for Infectious Diseases No. 1; Outpatient Clinic No.1 of Russian Academy of Sciences, Moscow, Russia

L. I Krasnoproshina

Mechnikov Research Institute of Vaccines and Sera; Gabrichevsky Moscow Research Institute of Epidemiology and Microbiology; Clinical Hospital for Infectious Diseases No. 1; Outpatient Clinic No.1 of Russian Academy of Sciences, Moscow, Russia

T. I Astakhova

Mechnikov Research Institute of Vaccines and Sera; Gabrichevsky Moscow Research Institute of Epidemiology and Microbiology; Clinical Hospital for Infectious Diseases No. 1; Outpatient Clinic No.1 of Russian Academy of Sciences, Moscow, Russia

N. S Zakharova

Mechnikov Research Institute of Vaccines and Sera; Gabrichevsky Moscow Research Institute of Epidemiology and Microbiology; Clinical Hospital for Infectious Diseases No. 1; Outpatient Clinic No.1 of Russian Academy of Sciences, Moscow, Russia

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Copyright (c) 2009 Zaytsev E.M., Mazurova I.K., Petrova M.S., Krasnoproshina L.I., Astakhova T.I., Zakharova N.S.

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