GENETIC CHARACTERISTIC OF TOXIGENICITY OF GROUP A STREPTOCOCCI CULTURES ISOLATED FROM PATIENTS WITH TONSILLITIS


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Abstract

Twenty-eight strains of group A streptococci (GAS) isolated from patients with lacunar and fibrinous-necrotic forms of tonsillitis during its 1 stor recurrent episode were tested for presence of genes of erythrogenic toxins A, B, C, and F using PCR assay. Obtained results allow to consider that clinical features of the disease (severity, repeatedness, clinical form) can be determined by toxigenicity of GAS. Express identification of S.pyogenes on the basis of detection of erythrogenic toxins genes spe B and spe F (mf) can be used for etiologic confirmation of diagnosis, whereas detection of erythrogenic toxins genes spe A and spe C can be recommended for prediction of the disease’s course.

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ГЕНЕТИЧЕСКАЯ ХАРАКТЕРИСТИКА ТОКСИГЕННОСТИ КУЛЬТУР СТРЕПТОКОККОВ ГРУППЫ А, ВЫДЕЛЕННЫХ ОТ БОЛЬНЫХ АНГИНОЙ
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About the authors

I. E Kravchenko

Kazan State Medical University; Sechenov Moscow Medical Academy; «Lagis» Ltd., Moscow, Russia

N. F Dmitrieva

Kazan State Medical University; Sechenov Moscow Medical Academy; «Lagis» Ltd., Moscow, Russia

A. S Eshchina

Kazan State Medical University; Sechenov Moscow Medical Academy; «Lagis» Ltd., Moscow, Russia

M. Yu Kirillov

Kazan State Medical University; Sechenov Moscow Medical Academy; «Lagis» Ltd., Moscow, Russia

Yu. M Timofeev

Kazan State Medical University; Sechenov Moscow Medical Academy; «Lagis» Ltd., Moscow, Russia

N. I Briko

Kazan State Medical University; Sechenov Moscow Medical Academy; «Lagis» Ltd., Moscow, Russia

References

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  2. Cunningham M.W. Pathogenesis of group A streptococcal infections. Clin. Microbiol Rev. 2000, 13: 470-511.
  3. Norby-Teglund A., Norgen M., Holm S.E. Similar cytokine induction profiles of a novel streptococcal exotoxin, MF, and pyrogenic exotoxins A and B. Infect. Immun. 1994, 62: 3731-3738.
  4. Kuo C.F., Lin Y.S., Chuang W.J. et al. Degradation of complement 3 by streptococcal pyrogenic exotoxin B inhibits complement activation and neutrophil opsonophagocytosis. Ibid. 2008, 76 (3): 1163-1169.
  5. Yu C.E., Ferretti J.J. Frequency of the erythrogenic toxin B and C genes (speB and speC) among clinical isolates of group A streptococci. Ibid. 1991, 59: 211-215.

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Copyright (c) 2009 Kravchenko I.E., Dmitrieva N.F., Eshchina A.S., Kirillov M.Y., Timofeev Y.M., Briko N.I.

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