THE MICROBIOTA OF LOWER AIRWAYS IN PATIENTS WITH CHRONIC OBSTRUCTIVE LUNG DISEASES

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Abstract

Aim. We aimed to estimate the composition and the detection frequency of bacterial species in induced sputum samples from patients with bronchial asthma (BA), chronic obstructive lung disease (COPD) and its combined phenotype (ACOS). Materials and methods. Bacteriological examination of samples of induced sputum in patients with chronic obstructive pulmonary diseases (BA, COPD) was carried out. Results. Patients with asthma-COPD overlap syndrome exhibit more diverse bacterial species composition as represented both by gram-positive Streptococcus sрp., Staphylococcus spр., gram-negative Klebsiella pneumoniaе, Escherichia coli, Serratia marcescens, Pseudomonas aeruginosa, Haemophilus influenzae, Burkholderia cepacia and rodlike bacterium Corynebacterium spр., Actinomyces spр. и Tsukamurella рaurometabola as compared to patients with only one diagnosis of COPD or asthma. In addition, we revealed the differences between microbiological diversity and predominance of Streptococcus spр, Neisseria subflava with decrease of Enterococcus sрр. in samples from patients with complicated forms of obstructive lung diseases as COPD and ACOS, with pulmonary emphysema and/or pneumosclerosis. Conclusion. The biodiversity of lung microbiome could be one of the pathology risk factors in patients with chronic lung diseases, on the other hand reflecting the structural morphological changes in the lung tissue as a result of sustainable inflammation.

About the authors

S. A. Mazurina

Mechnikov Research Institute of Vaccines а nd Sera

Author for correspondence.
Email: noemail@neicon.ru
Russian Federation

G. A. Danilina

Gamaleya Natiоnal Research Centre of Epidemiology and Microbiology

Email: noemail@neicon.ru
Russian Federation

M. Yu. Smirnova

Research Institute of Pulmonology

Email: noemail@neicon.ru
Russian Federation

G. L. Osipova

Research Institute of Pulmonology

Email: noemail@neicon.ru
Russian Federation

V. B. Gervazieva

Mechnikov Research Institute of Vaccines а nd Sera

Email: noemail@neicon.ru
Russian Federation

A. Yu. Konischeva

Mechnikov Research Institute of Vaccines а nd Sera

Email: noemail@neicon.ru
Russian Federation

T. P. Ospelnikova

Mechnikov Research Institute of Vaccines а nd Sera, Gamaleya Natiоnal Research Centre of Epidemiology and Microbiology

Email: noemail@neicon.ru
Russian Federation

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Copyright (c) 2018 Mazurina S.A., Danilina G.A., Smirnova M.Y., Osipova G.L., Gervazieva V.B., Konischeva A.Y., Ospelnikova T.P.

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