| Title |
Fig. 1. Titers of A/chicken/Kurgan/05/2005 (H5N1) virus in MDCK cells after their incubation of with Si~NH2/RNA and Si~NH2/siRNA nanocomplexes. C, virus control without samples. Si~NH2/RNA nanocomplexes containing RNA1–RNA8 (1–8), concentration of RNA in nanocomplexes is 0.5 µM; Si~NH2/siRNA nanocomplexes containing siRNA1/4, siRNA3/4, siRNA5/4 and siRNA7/4 (9–12), concentration of siRNA in nanocomplexes is 0.5 µM per one strand; ozeltamivir (13), 10 µg/mL or 32 µM; Si~NH2 (14), 0.5 mM; Si~NH2/siRNA9/10, nanocomplex containing unspecific siRNA9/10 (15). MOI, 0.01 TCID50/cell. The presented average values, standard deviations and differences in the titer values of the virus are calculated using the Spearman–Kerber method. Asterisks designate the difference between the control and the titer values of the virus obtained under the action of the studied series of nanocomplexes, at p < 0.05. |