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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="other" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Journal of microbiology, epidemiology and immunobiology</journal-id><journal-title-group><journal-title xml:lang="en">Journal of microbiology, epidemiology and immunobiology</journal-title><trans-title-group xml:lang="ru"><trans-title>Журнал микробиологии, эпидемиологии и иммунобиологии</trans-title></trans-title-group></journal-title-group><issn publication-format="print">0372-9311</issn><issn publication-format="electronic">2686-7613</issn><publisher><publisher-name xml:lang="en">Central Research Institute for Epidemiology</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">992</article-id><article-id pub-id-type="doi">10.36233/0372-9311-37</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>REVIEWS</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>ОБЗОРЫ</subject></subj-group><subj-group subj-group-type="article-type"><subject>Unknown</subject></subj-group></article-categories><title-group><article-title xml:lang="en">Current notions about etiopathogenic and genetics specific features of <italic>Сlostridium perfringens</italic> toxins</article-title><trans-title-group xml:lang="ru"><trans-title>Современные представления об этиопатогенетических и генетических особенностях токсинов <italic>Clostridium perfringens</italic></trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-6934-2223</contrib-id><name-alternatives><name xml:lang="en"><surname>Lobzin</surname><given-names>Yu. V.</given-names></name><name xml:lang="ru"><surname>Лобзин</surname><given-names>Ю. В.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>Yuri V. Lobzin — D. Sci. (Med.), Prof., Full Member of RAS, director</p><p>Saint Petersburg</p></bio><bio xml:lang="ru"><p>Лобзин Юрий Владимирович — д.м.н., проф., акад. РАН, директор</p><p>Санкт-Петербург</p></bio><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-8939-2973</contrib-id><name-alternatives><name xml:lang="en"><surname>Kvetnaya</surname><given-names>A. S.</given-names></name><name xml:lang="ru"><surname>Кветная</surname><given-names>А. С.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>Asya S. Kvetnaya — D. Sci. (Med.), Prof., leading researcher, Department of medical microbiology and molecular microbiology</p><p>Saint Petersburg</p></bio><bio xml:lang="ru"><p>Кветная Ася Степановна — д.м.н., проф., в.н.с. отдела медицинской микробиологии и молекулярной микробиологии</p><p>Санкт-Петербург</p></bio><email>asya41@mail.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-8927-3176</contrib-id><name-alternatives><name xml:lang="en"><surname>Skripchenko</surname><given-names>N. V.</given-names></name><name xml:lang="ru"><surname>Скрипченко</surname><given-names>Н. В.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>Natalya V. Skripchenko — D. Sci. (Med.), Prof., deputy director for science</p><p>Saint Petersburg</p></bio><bio xml:lang="ru"><p>Скрипченко Наталья Викторовна — д.м.н., проф., зам. директора по научной работе</p><p>Санкт-Петербург</p></bio><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-8071-3243</contrib-id><name-alternatives><name xml:lang="en"><surname>Zhelezova</surname><given-names>L. I.</given-names></name><name xml:lang="ru"><surname>Железова</surname><given-names>Л. И.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>Lyudmila I. Zhelezova — PhD (Med.), senior researcher, Department of medical microbiology and molecular microbiology</p><p>Saint Petersburg</p></bio><bio xml:lang="ru"><p>Железова Людмила Ильинична — к.м.н., с.н.с. отдела медицинской микробиологии и молекулярной микробиологии</p><p>Санкт-Петербург</p></bio><xref ref-type="aff" rid="aff1"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">Pediatric Research and Clinical Center for Infectious Diseases</institution></aff><aff><institution xml:lang="ru">Детский научно-клинический центр инфекционных болезней</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2021-03-04" publication-format="electronic"><day>04</day><month>03</month><year>2021</year></pub-date><volume>98</volume><issue>1</issue><issue-title xml:lang="en"/><issue-title xml:lang="ru"/><fpage>91</fpage><lpage>103</lpage><history><date date-type="received" iso-8601-date="2021-03-04"><day>04</day><month>03</month><year>2021</year></date><date date-type="accepted" iso-8601-date="2021-03-04"><day>04</day><month>03</month><year>2021</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2021, Lobzin Y.V., Kvetnaya A.S., Skripchenko N.V., Zhelezova L.I.</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2021, Лобзин Ю.В., Кветная А.С., Скрипченко Н.В., Железова Л.И.</copyright-statement><copyright-year>2021</copyright-year><copyright-holder xml:lang="en">Lobzin Y.V., Kvetnaya A.S., Skripchenko N.V., Zhelezova L.I.</copyright-holder><copyright-holder xml:lang="ru">Лобзин Ю.В., Кветная А.С., Скрипченко Н.В., Железова Л.И.</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/><license><ali:license_ref xmlns:ali="http://www.niso.org/schemas/ali/1.0/">https://creativecommons.org/licenses/by/4.0</ali:license_ref></license></permissions><self-uri xlink:href="https://microbiol.crie.ru/jour/article/view/992">https://microbiol.crie.ru/jour/article/view/992</self-uri><abstract xml:lang="en"><p>The review presents modern data on the genetics and etiopathogenetic features of <italic>Clostridium perfringens</italic> toxins, including the role of <italic>Clostridium perfringens</italic> enterotoxin, in the development of food poisoning and a number of intestinal diseases in humans, animals and birds.</p></abstract><trans-abstract xml:lang="ru"><p>В обзоре представлены современные сведения о генетике и этиопатогенетических особенностях токсинов и ферментов <italic>Clostridium рerfringens</italic>, в том числе о роли энтеротоксина <italic>Clostridium рerfringens</italic> в развитии пищевого отравления и ряда кишечных заболеваний людей, животных и птиц.</p></trans-abstract><kwd-group xml:lang="en"><kwd>review</kwd><kwd>Clostridium рerfringens</kwd><kwd>enterotoxin</kwd><kwd>pore-forming toxins</kwd><kwd>close contacts</kwd><kwd>claudin</kwd><kwd>genome</kwd><kwd>chromosomes</kwd><kwd>plasmids</kwd><kwd>review</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>Clostridium рerfringens</kwd><kwd>энтеротоксин</kwd><kwd>порообразующие токсины</kwd><kwd>плотные контакты</kwd><kwd>клаудины</kwd><kwd>геном</kwd><kwd>хромосомы</kwd><kwd>плазмиды</kwd><kwd>обзор</kwd></kwd-group><funding-group/></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>Kiu R., Hall L.J. 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