Journal of microbiology, epidemiology and immunobiologyJournal of microbiology, epidemiology and immunobiologyЖурнал микробиологии, эпидемиологии и иммунобиологии0372-93112686-7613Central Research Institute for Epidemiology98910.36233/0372-9311-62REVIEWSОБЗОРЫUnknownDysbiosis of intestinal microbiota in autism spectrum disorders: new horizons in search for pathogenetic approaches to therapy. Part 1. Features of intestinal microbiota in autism spectrum disordersНарушения кишечной микробиоты при расстройствах аутистического спектра: новые горизонты в поиске патогенетических подходов к терапии. Часть 1. Особенности кишечной микробиоты при расстройствах аутистического спектраhttps://orcid.org/0000-0002-1467-049XBlagonravovaA. S.БлагонравоваА. С.
Russian Federation

Anna S. Blagonravova — D. Sci. (Med.), Assoc. Prof., Vice-rector for research, prof., Department of epidemiology, microbiology and evidence-based medicine

Nizhny Novgorod

Благонравова Анна Сергеевна — д.м.н., доц., проректор по научной работе, проф. каф. эпидемиологии, микробиологии и доказательной медицины

Нижний Новгород

https://orcid.org/0000-0001-6155-1007ZhilyaevaT. V.ЖиляеваТ. В.
Russian Federation

Tatyana V. Zhilyaeva — PhD. (Med.), Assoc. Prof., Department of psychiatry

Nizhny Novgorod

Жиляева Татьяна Владимировна — к.м.н., доц. каф. психиатрии

Нижний Новгород

https://orcid.org/0000-0001-9317-4816KvashninaD. V.КвашнинаД. В.
Russian Federation

Darya V. Kvashnina — PhD. (Med.), senior lecturer, Department of epidemiology, microbiology and evidence-based medicine

Nizhny Novgorod

Квашнина Дарья Валерьевна — к.м.н., старший преподаватель каф. эпидемиологии, микробиологии и доказательной медицины

Нижний Новгород

daria_tsariova@mail.ruPrivolzhsky Research Medical UniversityПриволжский исследовательский медицинский университет0403202198165720403202104032021Copyright ©; 2021, Blagonravova A.S., Zhilyaeva T.V., Kvashnina D.V.Copyright ©; 2021, Благонравова А.С., Жиляева Т.В., Квашнина Д.В.2021Blagonravova A.S., Zhilyaeva T.V., Kvashnina D.V.Благонравова А.С., Жиляева Т.В., Квашнина Д.В.https://creativecommons.org/licenses/by/4.0https://microbiol.crie.ru/jour/article/view/989

The first part of the literature review on the role of intestinal microbiota dysbiosis in the pathogenesis of autism spectrum disorders (ASD) includes recent data published in the literature on the features of the quantitative and qualitative composition of the intestinal microbiota in patients with autism. It was shown that an excessive presence of Clostridium was detected in ASD, and evidence was presented showing the possible participation of these bacteria in the development of autism symptoms. Contradictory research results on an increase in a number of other pathogenic bacteria and, conversely, a decrease in the number of bacteria necessary to maintain the normal functioning of the intestine and the host organism as a whole are presented. The possible role of Candida albicans in ASD, requiring further study, is reported. Possible causes of contradictions in the results of studies on this topic are discussed.

Первая часть обзора литературы, посвященного роли нарушений кишечной микробиоты в патогенезе расстройств аутистического спектра (РАС), включает последние опубликованные данные об особенностях количественного и качественного состава кишечной микробиоты у пациентов с аутизмом. Показано, что при РАС обнаружено избыточное присутствие Clostridium spp., представлены данные, свидетельствующие о возможном участии этих бактерий в развитии симптомов аутизма. Приведены противоречивые результаты исследований об увеличении численности ряда других патогенных бактерий и, наоборот, снижении количества бактерий, необходимых для поддержания нормального функционирования кишечника и организма хозяина в целом. Сообщается о возможной роли Candida albicans при РАС, требующей дальнейшего изучения. Обсуждаются возможные причины противоречий в результатах исследований, посвященных данной теме.

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