Journal of microbiology, epidemiology and immunobiologyJournal of microbiology, epidemiology and immunobiology0372-93112686-7613Central Research Institute for Epidemiology86910.36233/0372-9311-2020-97-4-4Research ArticleMolecular epidemiological features of the Coxsackievirus A10 circulation in the Far Eastern Federal District of RussiaButakovaLyudmila V.researcher, Far Eastern regional scientific methodological center for the study of enterovirus infectionevi.khv@mail.ruhttps://orcid.org/0000-0002-7238-3691SapegaElena Yu.PhD (Med.), leading researcher, Head, Far Eastern regional scientific methodological center for the study of enterovirus infectionfake@neicon.ruhttps://orcid.org/0000-0003-4438-6913TrotsenkoOlga E.D. Sci. (Med.), Directorfake@neicon.ruhttps://orcid.org/0000-0003-3050-4472Khabarovsk Research Institute of Epidemiology and Microbiology020920209743243300209202002092020Copyright © 2020, Butakova L.V., Sapega E.Y., Trotsenko O.E.2020<p>Background. Increase in incidence rates of enterovirus infections in the Far Eastern Federal District of Russia is observed annually. There is a wide genetic diversity of circulating non-polio enteroviruses. Some of them have been constantly identified for a number of years in the population of the district, including the Coxsackie A10 virus.<br />Purpose. To study the features of the Coxsackievirus A10 circulation in the Far Eastern Federal District of Russia in 20142018.<br />Methods. For this work, 117 Coxsackievirus A10 complete sequences of the VP1 gene were used, which were isolated in the Far Eastern Federal District of Russia in 20142018.<br />Results. Phylogenetic analysis revealed two Coxsackievirus A10 lineages in the Far Eastern Federal District of Russia in 2014-2018, while their simultaneous circulation was noted in the Sakhalin region in 2017. Active population migration contributes to the widespread distribution of Coxsackievirus A10 in border areas with the formation of epidemic variants.<br />Conclusion. Coxsackievirus A10 is one of the most relevant types of non-polio enteroviruses for the Far Eastern Federal District of Russia. Phylogenetic analysis revealed its genetic diversity and suggested both European and Asian origin of the obtained strains.</p>enterovirusCoxsackievirus A10clusterphylogenetic analysisэнтеровирусКоксаки А10кластерфилогенетический анализ[Pallansch M.A., Roos R. Enteroviruses: Polioviruses, coxsackieviruses, echoviruses, and newer enteroviruses. In: Knipe D.M., Howley P.M., eds. Fields Virology. Philadelphia: Lippincott Williams & Wilkins; 2007: 839-93.][EV-A Prototypes. Available at: http://www.picornaviridae.com/enterovirus/prototypes/ev-a_prototypes.htm][Tapparel C., Siegrist F., Petty T.J., Kaiser L. Picornavirus and enterovirus diversity with associated human diseases. Infect. Genet. Evol. 2013; 14: 282-93. DOI: http://doi.org/10.1016/j.meegid.2012.10.016][Chen M., He S., Yan Q., Xu X., Wu W., Ge S., et al. Severe hand, foot and mouth disease associated with Coxsackievirus A10 infections in Xiamen, China in 2015. J. Clin. Virol. 2017; 93: 20‐4. DOI: http://doi.org/10.1016/j.jcv.2017.05.011][Fuschino M.E., Lamson D.M., Rush K., Carbone L.S., Taff M.L., Hua Z., et al. Detection of coxsackievirus A10 in multiple tissues of a fatal infant sepsis case. J. Clin. Virol. 2012; 53(3): 259-61. DOI: http://doi.org/10.1016/j.jcv.2011.12.011][Lu Q.B., Zhang X.A., Wo Y., Xu H.M., Li X.J., Wang X.J., et al. Circulation of Coxsackievirus A10 and A6 in hand-foot-mouth disease in China, 2009–2011. PLoS One. 2012; 7(12): e52073. DOI: http://doi.org/10.1371/journal.pone.0052073][Blomqvist S., Klemola P., Kaijalainen S., Paananen A., Simonen M.L., Vuorinen T., et al. Co-circulation of coxsackieviruses A6 and A10 in hand, foot and mouth disease outbreak in Finland. J. Clin. Virol. 2010; 48(1): 49-54. DOI: http://doi.org/10.1016/j.jcv.2010.02.002][Davia J.L., Bel P.H., Ninet V.Z., Bracho M.A., González-Candelas F., Salazar A., et al. Onychomadesis outbreak in Valencia, Spain associated with hand, foot, and mouth disease caused by enteroviruses. Pediatr. Dermatol. 2011; 28(1): 1-5. DOI: http://doi.org/10.1111/j.1525-1470.2010.01161.x][Wu Y., Yeo A., Phoon M.C., Tan E.L., Poh C.L., Quak S.H., et al. The largest outbreak of hand; foot and mouth disease in Singapore in 2008: the role of enterovirus 71 and coxsackievirus A strains. Int. J. Infect. Dis. 2010; 14(12): e1076-81. DOI: http://doi.org/10.1016/j.ijid.2010.07.006][Mirand A., Henquell C., Archimbaud C., Ughetto S., Antona D., Bailly J.L., et al. Outbreak of hand, foot and mouth disease/herpangina associated with coxsackievirus A6 and A10 infections in 2010, France: a large citywide, prospective observational study. Clin. Microbiol. Infect. 2012; 18(5): E110-8. DOI: http://doi.org/10.1111/j.1469-0691.2012.03789.x][Yang Q., Ding J., Cao J., Huang Q., Hong C., Yang B. Epidemiological and etiological characteristics of hand, foot, and mouth disease in Wuhan, China from 2012 to 2013: outbreaks of coxsackieviruses A10. J. Med. Virol. 2015; 87(6): 954-60. DOI: http://doi.org/10.1002/jmv.24151][Лукашев А.Н., Голицына Л.Н., Вакуленко Ю.А., Ахмадишина Л.В., Романенкова Н.И., Сапега Е.Ю. и др. Современные возможности и направления развития молекулярно-эпидемиологического мониторинга в надзоре за энтеровирусными инфекциями. Опыт Российской Федерации. Инфекция и иммунитет. 2018; 8(4): 452-64. DOI: http://doi.org/10.15789/2220-7619-2018-4-452-464]