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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="research-article" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Journal of microbiology, epidemiology and immunobiology</journal-id><journal-title-group><journal-title xml:lang="en">Journal of microbiology, epidemiology and immunobiology</journal-title><trans-title-group xml:lang="ru"><trans-title>Журнал микробиологии, эпидемиологии и иммунобиологии</trans-title></trans-title-group></journal-title-group><issn publication-format="print">0372-9311</issn><issn publication-format="electronic">2686-7613</issn><publisher><publisher-name xml:lang="en">Central Research Institute for Epidemiology</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">7278</article-id><article-id pub-id-type="doi">10.36233/0372-9311-327</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>ORIGINAL RESEARCHES</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>ОРИГИНАЛЬНЫЕ ИССЛЕДОВАНИЯ</subject></subj-group><subj-group subj-group-type="article-type"><subject>Research Article</subject></subj-group></article-categories><title-group><article-title xml:lang="en">Clinical and epidemiological characteristics of cancers associated with human papillomavirus in the regions of North-West Russia</article-title><trans-title-group xml:lang="ru"><trans-title>Клинико-эпидемиологическая характеристика злокачественных новообразований, ассоциированных с вирусом папилломы человека, в регионах Северо-Запада России</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-9921-3505</contrib-id><name-alternatives><name xml:lang="en"><surname>Lyalina</surname><given-names>Liudmila V.</given-names></name><name xml:lang="ru"><surname>Лялина</surname><given-names>Людмила Владимировна</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>D. Sci. (Med.), Professor, Head, Laboratory of the epidemiology of infectious and non-infectious diseases</p></bio><bio xml:lang="ru"><p>д.м.н., профессор, зав. лаб. эпидемиологии инфекционных и неинфекционных заболеваний</p></bio><email>lvlyalina777@yandex.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-1268-6172</contrib-id><name-alternatives><name xml:lang="en"><surname>Kholopov</surname><given-names>Dmitry V.</given-names></name><name xml:lang="ru"><surname>Холопов</surname><given-names>Дмитрий Вячеславович</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>postgraduate student</p></bio><bio xml:lang="ru"><p>аспирант</p></bio><email>lvlyalina777@yandex.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-1334-8191</contrib-id><name-alternatives><name xml:lang="en"><surname>Yazenok</surname><given-names>Arkady V.</given-names></name><name xml:lang="ru"><surname>Язенок</surname><given-names>Аркадий Витальевич</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>Cand. Sci. (Med.), Associated Professor, director, Medical Information and Analytical Center</p></bio><bio xml:lang="ru"><p>д.м.н., доцент, директор Медицинского информационно-аналитического центра</p></bio><email>lvlyalina777@yandex.ru</email><xref ref-type="aff" rid="aff2"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-4218-0228</contrib-id><name-alternatives><name xml:lang="en"><surname>Khizha</surname><given-names>Valentin V.</given-names></name><name xml:lang="ru"><surname>Хижа</surname><given-names>Валентин Васильевич</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>Cand. Sci. (Med.), Head, Department of medical statistics of tumor diseases</p></bio><bio xml:lang="ru"><p>к.м.н., начальник отдела медицинской статистики опухолевых заболеваний Медицинского информационно-аналитического центра</p></bio><email>lvlyalina777@yandex.ru</email><xref ref-type="aff" rid="aff2"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-1700-1128</contrib-id><name-alternatives><name xml:lang="en"><surname>Topuzov</surname><given-names>Eldar E.</given-names></name><name xml:lang="ru"><surname>Топузов</surname><given-names>Эльдар Эскендерович</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>D. Sci. (Med.), Professor, chief doctor</p></bio><bio xml:lang="ru"><p>д.м.н., профессор, главный врач Городского клинического онкологического диспансера</p></bio><email>lvlyalina777@yandex.ru</email><xref ref-type="aff" rid="aff3"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-0029-7150</contrib-id><name-alternatives><name xml:lang="en"><surname>Kasatkin</surname><given-names>Evgeny V.</given-names></name><name xml:lang="ru"><surname>Касаткин</surname><given-names>Евгений Владимирович</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>Cand. Sci. (Med.), chief doctor, Skin and Venereological Dispensary No. 8</p></bio><bio xml:lang="ru"><p>к.м.н, главный врач Кожно-венерологического диспансера № 8</p></bio><email>lvlyalina777@yandex.ru</email><xref ref-type="aff" rid="aff4"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-6842-7201</contrib-id><name-alternatives><name xml:lang="en"><surname>Goryaev</surname><given-names>Evgeny A.</given-names></name><name xml:lang="ru"><surname>Горяев</surname><given-names>Евгений Александрович</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>Head, Prevention department, Center for the Prevention and Control of AIDS and Infectious Diseases of the Leningrad Region</p></bio><bio xml:lang="ru"><p>зав. отделом профилактики Центра по профилактике и борьбе со СПИД и инфекционными заболеваниями Ленинградской области</p></bio><email>lvlyalina777@yandex.ru</email><xref ref-type="aff" rid="aff5"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-2905-2635</contrib-id><name-alternatives><name xml:lang="en"><surname>Zadorkina</surname><given-names>Tatiana G.</given-names></name><name xml:lang="ru"><surname>Задоркина</surname><given-names>Татьяна Геннадьевна</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>Cand. Sci. (Med.), chief doctor</p></bio><bio xml:lang="ru"><p>к.м.н., главный врач</p></bio><email>lvlyalina777@yandex.ru</email><xref ref-type="aff" rid="aff6"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-2704-7832</contrib-id><name-alternatives><name xml:lang="en"><surname>Molchanova</surname><given-names>Zhanna R.</given-names></name><name xml:lang="ru"><surname>Молчанова</surname><given-names>Жанна Руслановна</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>chief specialist expert, Department of epidemiological surveillance and sanitary protection of the territory, Office of Russian Consumer Supervision in the Kaliningrad Region</p></bio><bio xml:lang="ru"><p>главный специалист эксперт отдела эпидемиологического надзора и санитарной охраны территории Управления Роспотребнадзора по Калининградской области</p></bio><email>lvlyalina777@yandex.ru</email><xref ref-type="aff" rid="aff7"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">St. Petersburg Pasteur Institute</institution></aff><aff><institution xml:lang="ru">Санкт-Петербургский научно-исследовательский институт эпидемиологии и микробиологии имени Пастера</institution></aff></aff-alternatives><aff-alternatives id="aff2"><aff><institution xml:lang="en">Medical information and analytical center</institution></aff><aff><institution xml:lang="ru">Медицинский информационно-аналитический центр</institution></aff></aff-alternatives><aff-alternatives id="aff3"><aff><institution xml:lang="en">Saint-Petersburg City Oncology Clinic</institution></aff><aff><institution xml:lang="ru">Городской клинический онкологический диспансер, Санкт-Петербург</institution></aff></aff-alternatives><aff-alternatives id="aff4"><aff><institution xml:lang="en">Skin and venereological dispensary No. 8, St. Petersburg</institution></aff><aff><institution xml:lang="ru">Кожно-венерологический диспансер № 8, Санкт-Петербург</institution></aff></aff-alternatives><aff-alternatives id="aff5"><aff><institution xml:lang="en">Center for the Prevention and Control of AIDS and Infectious Diseases of the Leningrad Region</institution></aff><aff><institution xml:lang="ru">Центр по профилактике и борьбе со СПИД и инфекционными заболеваниями Ленинградской области</institution></aff></aff-alternatives><aff-alternatives id="aff6"><aff><institution xml:lang="en">Center for Specialized Types of Medical Care of the Kaliningrad region</institution></aff><aff><institution xml:lang="ru">Центр специализированных видов медицинской помощи Калининградской области</institution></aff></aff-alternatives><aff-alternatives id="aff7"><aff><institution xml:lang="en">Department of the Federal Service for Supervision of Consumer Rights Protection and Human Welfare in the Kaliningrad Region</institution></aff><aff><institution xml:lang="ru">Управление Роспотребнадзора по Калининградской области</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2023-04-03" publication-format="electronic"><day>03</day><month>04</month><year>2023</year></pub-date><volume>100</volume><issue>1</issue><issue-title xml:lang="en"/><issue-title xml:lang="ru"/><fpage>52</fpage><lpage>64</lpage><history><date date-type="received" iso-8601-date="2023-04-03"><day>03</day><month>04</month><year>2023</year></date><date date-type="accepted" iso-8601-date="2023-04-03"><day>03</day><month>04</month><year>2023</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2023, Lyalina L.V., Kholopov D.V., Yazenok A.V., Khizha V.V., Topuzov E.E., Kasatkin E.V., Goryaev E.A., Zadorkina T.G., Molchanova Z.R.</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2023, Лялина Л.В., Холопов Д.В., Язенок А.В., Хижа В.В., Топузов Э.Э., Касаткин Е.В., Горяев Е.А., Задоркина Т.Г., Молчанова Ж.Р.</copyright-statement><copyright-year>2023</copyright-year><copyright-holder xml:lang="en">Lyalina L.V., Kholopov D.V., Yazenok A.V., Khizha V.V., Topuzov E.E., Kasatkin E.V., Goryaev E.A., Zadorkina T.G., Molchanova Z.R.</copyright-holder><copyright-holder xml:lang="ru">Лялина Л.В., Холопов Д.В., Язенок А.В., Хижа В.В., Топузов Э.Э., Касаткин Е.В., Горяев Е.А., Задоркина Т.Г., Молчанова Ж.Р.</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/><license><ali:license_ref xmlns:ali="http://www.niso.org/schemas/ali/1.0/">https://creativecommons.org/licenses/by/4.0</ali:license_ref></license></permissions><self-uri xlink:href="https://microbiol.crie.ru/jour/article/view/7278">https://microbiol.crie.ru/jour/article/view/7278</self-uri><abstract xml:lang="en"><p><bold>Introduction.</bold> The leading role of the human papillomavirus in the etiopathogenesis of malignant neoplasms of some localizations is generally recognized. Vaccines that are used in the world and in Russia for the prevention of papillomavirus infection create the basis for the elimination of diseases associated with the human papillomavirus in the future.</p> <p><bold>The aim</bold> of the study is to determine the regional, gender and age-specific features of cancers associated with the human papillomavirus to substantiate the development of a unified system of epidemiological surveillance and vaccination.</p> <p><bold>Materials and methods.</bold> The retrospective epidemiological analysis of the incidence of cancers associated with the human papillomavirus and mortality due to these neoplasms in the regions of the North-Western Federal District of Russia in 2011–2020 was carried out based on data from Statistic Form 7 "Information on malignant neoplasms" and the Population cancer Registers of St. Petersburg (13,117 cases), Leningrad region (3204 cases) and the Kaliningrad region (2898 cases).</p> <p><bold>Results.</bold> In the structure of cancers associated with the human papillomavirus in St. Petersburg, Leningrad and Kaliningrad regions, more than 90% of men had tumors of the oral cavity, oropharynx and larynx, more than 60% of women had cervical cancer. Regional and age-specific features of the incidence of cervical cancer and mortality from this pathology have been established. Statistically significant differences in the incidence of cancer of the head and neck, anus and anal canal in different age groups of the male and female population were revealed.</p> <p><bold>Conclusion.</bold> As a result of the study, regional, gender and age-specific features of the incidence of human papillomavirus-associated malignant neoplasms in the North-West of Russia were established. These data should be used to develop a system of epidemiological surveillance of papillomavirus infection and vaccination program.</p></abstract><trans-abstract xml:lang="ru"><p><bold>Введение. </bold>Ведущая роль вируса папилломы человека (ВПЧ) в этиопатогенезе злокачественных новообразований (ЗНО) некоторых локализаций является общепризнанной. Применяемые в мире и России вакцины для профилактики папилломавирусной инфекции создают основу для элиминации заболеваний, ассоциированных с ВПЧ, в будущем.</p> <p><bold>Цель </bold>исследования — определение региональных, гендерных и возрастных особенностей ЗНО, ассоциированных с ВПЧ, для обоснования развития единой системы эпидемиологического надзора и вакцинопрофилактики.</p> <p><bold>Материалы и методы. </bold>Ретроспективный эпидемиологический анализ заболеваемости ЗНО, ассоциированными с ВПЧ, и смертности от этих неоплазий в регионах Северо-Западного федерального округа России проведён за 2011–2020 гг. по данным формы № 7 «Сведения о злокачественных новообразованиях» и Популяционных раковых регистров Санкт-Петербурга (13 117 случаев), Ленинградской (3204 случая) и Калининградской (2898 случаев) областей.</p> <p><bold>Результаты.</bold> В структуре ЗНО, ассоциированных с ВПЧ, в Санкт-Петербурге, Ленинградской и Калининградской областях у мужчин более 90% составили опухоли полости рта, ротоглотки и гортани, среди женщин более 60% занимает рак шейки матки. Установлены региональные и возрастные особенности заболеваемости раком шейки матки и смертности от этой патологии. Выявлены статистически значимые различия заболеваемости раком головы и шеи, ануса и анального канала различных возрастных групп мужчин и женщин.</p> <p><bold>Заключение. </bold>В результате проведённого исследования установлены региональные, гендерные и возрастные особенности заболеваемости ЗНО, ассоциированными с ВПЧ, на Северо-Западе России. Эти данные целесообразно использовать для развития единой системы эпидемиологического надзора и вакцинопрофилактики папилломавирусной инфекции и связанных с ней неоплазий.</p></trans-abstract><kwd-group xml:lang="en"><kwd>human papillomavirus</kwd><kwd>cancer</kwd><kwd>regional</kwd><kwd>gender and age features in North-West of Russia</kwd><kwd>morbidity</kwd><kwd>mortality</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>вирус папилломы человека</kwd><kwd>злокачественные новообразования</kwd><kwd>региональные</kwd><kwd>гендерные и возрастные особенности</kwd><kwd>Северо-Запад России</kwd><kwd>заболеваемость</kwd><kwd>смертность</kwd></kwd-group><funding-group/></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>Morales-Sánchez A., Fuentes-Pananá E. Human viruses and cancer. 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