Journal of microbiology, epidemiology and immunobiologyJournal of microbiology, epidemiology and immunobiologyЖурнал микробиологии, эпидемиологии и иммунобиологии0372-93112686-7613Central Research Institute for Epidemiology5610.36233/0372-9311-2016-3-97-104REVIEWSОБЗОРЫPATHOGENICITY FACTORS OF CORYNEBACTERIUM NON DIPHTHERIAEФАКТОРЫ ПАТОГЕННОСТИ CORYNEBACTERIUM NON DIPHTHERIAEKharseevaG. G.ХарсееваГ. Г.
Russian Federation
VoroninaN. A.ВоронинаН. А.
Russian Federation
Rostov State Medical UniversityРостовский государственный медицинский университет280620169339710410042019Copyright ©; 2016, Kharseeva G.G., Voronina N.A.Copyright ©; 2016, Харсеева Г.Г., Воронина Н.А.2016Kharseeva G.G., Voronina N.A.Харсеева Г.Г., Воронина Н.А.https://creativecommons.org/licenses/by/4.0https://microbiol.crie.ru/jour/article/view/56

Pathogenicity factors of Corynebacterium non diphtheriae - pili, microcapsule, cell wall, pathogenicity enzymes, toxins, that determine the ability of microorganisms to consequentially interact with epithelium of entry gates of the organism, replicate in vivo, overcome cell and humoral mechanisms of protection, are examined in the review. Particular attention in the paper is given to species of non-diphtheria corynebacteria, that are pathogenic for human and able to produce toxins - Corynebacterium ulcerans and Corynebacterium pseudotuberculosis. Mechanisms of expression regulation of PLD-exotoxins, its interaction with immune system cells are described.

В обзоре рассмотрены факторы патогенности Corynebacterium non diphtheriae - пили, микрокапсула, клеточная стенка, ферменты патогенности, токсины, которые обусловливают способность микроорганизмов последовательно взаимодействовать с эпителием входных ворот организма, размножаться in vivo, преодолевать клеточные и гуморальные механизмы защиты. Отдельное внимание в статье уделено видам недифтерийных коринебактерий, патогенных для человека и способных продуцировать токсины - Corynebacterium ulcerans и Corynebacterium pseudotuberculosis. Описаны механизмы регуляции экспрессии PLD-экзотоксина, его взаимодействие с клетками иммунной системы.

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