Journal of microbiology, epidemiology and immunobiologyJournal of microbiology, epidemiology and immunobiology0372-93112686-7613Central Research Institute for Epidemiology47810.36233/0372-9311-2019-5-95-102Genetic diversity of rubella virus at the present stage of rubella elimination and congenital rubella prevention programsChekhlyaevaT. S.fake@neicon.ruShulgaS. V.fake@neicon.ruErokhovD. V.fake@neicon.ruTikhonovaN. T.fake@neicon.ruZverevV. V.fake@neicon.ruGabrichevsky Moscow Research Institute of Epidemiology and MicrobiologySechenov First Moscow State Medical University21112019965951021911201919112019Copyright © 2019, Chekhlyaeva T.S., Shulga S.V., Erokhov D.V., Tikhonova N.T., Zverev V.V.2019The review is devoted to an analysis of the genetic diversity of the rubella virus. Historical and geographical data of the circulation of various genotypes of the rubella virus were presented. The tendency to reduce the genetic diversity of the virus in the world as a result of the rubella elimination programs have been shown.rubellacongenital rubella syndromeCRSrubella virusrubella eliminationrubella genotypeкраснухасиндром врожденной краснухиСВКвирус краснухиэлиминация краснухигенотип вируса краснухи[1. База данных эпиднадзора за краснухой на основе определения нуклеотидных последовательностей (RubeNS). www.who-rubella.org .][2. Зверев В.В., Десятскова Р.Г. Врожденная краснуха. Бюллетень «Вакцинация. Новости вакцинопрофилактики». 2004, 6 (36).][3. Компьютеризованная информационная система по инфекционным заболеваниям (ЦИСИЗ). http://data.euro.who.int/cisid/.][4. Лаврентьева И.Н., Семериков В.В., Жебрун А.Б., Фельдблюм И.В., Марков А.В. Краснуха в России: изменчивость возбудителя в период вакцинопрофилактики. Журн. микробиол. 2008, 3: 26-31.][5. Программа «Элиминация кори и краснухи в Российской Федерации» (2016 — 2020 гг.). https://rospotrebnadzor.ru/deyatelnost/epidemiological-surveillance/?ELEMENT_ID=5968.][6. Элиминация кори и краснухи и предупреждение врожденной краснушной инфекции. Стратегический план Европейского региона ВОЗ 2005-2010 гг. http://www.euro.who.int/__data/assets/pdf_file/0019/79030/E87772R.pdf.][7. Ai J., Xie Z., Liu G. et al. Etiology and prognosis of acute viral encephalitis and meningitis in Chinese children: a multicentre prospective study. BMC Infect Dis. 2017, 17(1): 494.][8. Boehlen F., Balavoine J.F, de Moerloose P. Severe thrombocytopenic purpura due to rubella infection in a patient with systemic lupus erythematosus. Lupus. 2003, 2(2): 144-146.][9. Catlin F. Prevention of hearing impairment from infection and ototoxic drugs. Arch Otolaryngol. 1985, 111 (6): 377-384.][10. Dominguez G., Wang C-Y., Frey T.K. Sequence of the genome RNA of rubella virus: evidence for genetic rearrangement during togavirus evolution. Virology. 1990, 177: 225.][11. Fenner F., Pereira H.G., Porterfield J.S. et al. Family and generic names for viruses approved by the International Committee on Taxonomy of Viruses, June 1974. Intervirology, 3(3), 193-198.][12. Figueiredo C.A., Klautau G.B., Afonso A.M. et al. Isolation and genotype analysis of rubella virus from a case of Guillain-Barrй syndrome. J. Clin. Virol. 2008, 43(3): 343-345.][13. Frey T.K., Abernathy E.S., Bosma T.J. et al. Molecular analysis of rubella virus epidemiology across three continents, North America, Europe, and Asia, 1961-1997. J. Infect. Dis. 1998, 178 (3): 642-650.][14. Global and regional immunization profile. European Region. 2018. https://www.who.int/immunization/monitoring_surveillance/data/gs_eurprofile.pdf?ua=1.][15. Global measles and rubella laboratory network support for elimination goals, 2010—2015. Wkly Epidemiol. Rec. 2016, 91: 240-246.][16. International Committee on Taxonomy of Viruses (ICTV): Taxonomy release 2018b. https://talk.ictvonline.org/files/master-species-lists/m/msl/8266.][17. Jin L., Thomas B. Application of molecular and serological assays to case based investigations of rubella and congenital rubella syndrome. J. Med. Virol. 2007, 79 (7): 1017-1024.][18. Katow S., Minahara H., Fukushima M. et al. Molecular epidemiology of rubella by nucleotide sequences of the rubella virus E1 gene in three East Asian countries. J. Infect. Dis. 1997, 176 (3): 602-616.][19. Marks M., Marks J.L. Viral arthritis. Clin. Med. (Lond). 2016, 16(2): 129-134.][20. Martinez-Torres A.O., Mosquera M.M., Sanz J.C. et al. Phylogenetic analysis of rubella virus strains from an outbreak in Madrid, Spain, from 2004 to 2005. J. Clin. Microbiol. 2009, 47 (1): 158-163.][21. Pether J.V., Caul E.O., Betteridge T.J. et al. Fatal pneumonia after glandular fever and rubella. Lancet. 1989, 1(8648): 1210.][22. Rubella — Elimination of rubella and congenital rubella syndrome in the Americas. https://www.paho.org/hq/index.php?option=com_content&view=article&id=10801:2015-elimination-rubellacongenital-syndrome-americas&Itemid=40721&lang=en.][23. Rubella virus nomenclature update: 2013. Wkly Epidemiol. Rec. 2013, 32: 337-348.][24. Standardization of the nomenclature for genetic characteristics of wild-type rubella viruses. Wkly Epidemiol. Rec. 2005, 14: 126-132.][25. The role of extended and whole genome sequencing for tracking transmission of measles and rubella viruses: report from the Global Measles and Rubella Laboratory Network meeting, 2017. Wkly Epidemiol. Rec. 2018, 93: 55-59.][26. Update of standard nomenclature for wild-type rubella viruses, 2007. Wkly Epidemiol. Rec. 2007, 84: 216-222.][27. Vauloup-Fellous C., Hubschen J.M., Abernathy E.S. et al. Phylogenetic analysis of rubella viruses involved in congenital rubella infections in France between 1995 and 2009. J. Clin. Microbiol. 2010, 48 (7): 2530-2535.][28. World Health Organization. Global Measles and Rubella strategic plan 2012-2020. 2011. https://apps.who.int/iris/bitstream/handle/10665/44855/9789241503396_eng.pdf.][29. Zheng D.P., Frey T.K., Icenogle J. et al. Global distribution of rubella virus genotypes. Emerging Infect. Dis. 2003, 9 (12): 1523-1530.][30. Zheng D.P., Zhou Y.M., Zhao K. et al. Characterization of genotype II Rubella virus strains. Arch. Virol. 2003, 148 (9): 1835-1850.][31. Zheng D.P., Zhu H., Revello M.G. et al. Phylogenetic analysis of rubella virus isolated during a period of epidemic transmission in Italy, 1991-1997. J. Infect. Dis. 2003, 187 (10): 1587-1597.]