Journal of microbiology, epidemiology and immunobiologyJournal of microbiology, epidemiology and immunobiologyЖурнал микробиологии, эпидемиологии и иммунобиологии0372-93112686-7613Central Research Institute for Epidemiology44010.36233/0372-9311-2019-4-105-115REVIEWSОБЗОРЫAkkermansia muciniphila is a new universal probiotic on the basis of live human commensal gut bacteria: the reality or legend?Аkkermansia muciniphila — новый универсальный пробиотик на основе живых комменсальных бактерий кишечника человека: действительность или легенда?ShenderovB. A.ШендеровБ. А.
Russian Federation

Шендеров Борис Аркадьевич, д.м.н., проф.

119121, Москва, Погодинская ул., 10. стр 1, р.т. (499)248-43-93

YudinS. M.ЮдинС. М.
Russian Federation

Москва

ZagaynovaA. V.ЗагайноваА. В.
Russian Federation

Москва

ShevyrevaM. P.ШевыреваМ. П.
Russian Federation

Москва

Centre for Strategic Planning and Management of Biomedical Health RisksЦентр стратегического планирования и управления медико-биологическими рисками здоровьюSechenov First Moscow State Medical UniversityПервый московский государственный медицинский университет им. И.М.Сеченова020920199641051150209201902092019Copyright ©; 2019, Shenderov B.A., Yudin S.M., Zagaynova A.V., Shevyreva M.P.Copyright ©; 2019, Шендеров Б.А., Юдин С.М., Загайнова А.В., Шевырева М.П.2019Shenderov B.A., Yudin S.M., Zagaynova A.V., Shevyreva M.P.Шендеров Б.А., Юдин С.М., Загайнова А.В., Шевырева М.П.https://creativecommons.org/licenses/by/4.0https://microbiol.crie.ru/jour/article/view/440

Contemporary information on biology of Akkermansia muciniphila and the role of these gut mucolytic anaerobic bacteria in physiological functions, metabolic and signaling reactions in human health and diseases are presented in the review. Established by foreign researchers, favorable and negative effects are associated with the presence in these gram-negative bacteria specific surface membrane proteins, the production of certain short-chain fatty acids and endotoxin, as well as with the ability degrading mucin, changing intestinal barrier function and synthesizing some neurotransmitters. Prospects and difficulties of creation of new microbial nutraceuticals and drugs on the basis of living cells of A. muciniphila or their specific low-molecular components and metabolites are considered.

В обзоре представлены современные сведения о биологии Аkkermansia muciniphila, комменсального представителя анаэробной кишечной микробиоты, обладающего выраженной муколитической активностью и способного модулировать различные функции, метаболические и сигнальные реакция у здоровых и больных людей. Установленные зарубежными исследователями благоприятные и негативные эффекты связывают с наличием у этих грамотрицательных бактерий специфических поверхностных мембранных белков, продукцией определенных короткоцепочечных жирных кислот, деградацией муцина, изменением барьерной функции кишечника, продукцией эндотоксина, а также синтезом некоторых нейромедиаторов. Рассматриваются перспективы и сложности создания новых микробных нутрицевтиков и лекарственных препаратов на основе живых клеток A. muciniphila или их специфических низкомолекулярных компонентов и метаболитов.

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