Journal of microbiology, epidemiology and immunobiologyJournal of microbiology, epidemiology and immunobiologyЖурнал микробиологии, эпидемиологии и иммунобиологии0372-93112686-7613Central Research Institute for Epidemiology42110.36233/0372-9311-2018-3-105-116REVIEWSОБЗОРЫIN VITRO DIAGNOSIS FOR EBOLA VIRUS DISEASE. A COMPARISON OF CURRENT TECHNIQUES AND DIAGNOSTIC ASSAYSКЛИНИЧЕСКАЯ ЛАБОРАТОРНАЯ ДИАГНОСТИКА ЛИХОРАДКИ ЭБОЛА. АНАЛИЗ СУЩЕСТВУЮЩИХ МЕТОДИК И ДИАГНОСТИЧЕСКИХ СРЕДСТВSementsovaA. O.СеменцоваА. О.
Russian Federation

Koltsovo, Novosibirsk Region

630559 п. Кольцово, Новосибирская обл.

DedkovV. G.ДедковВ. Г.
Russian Federation
TernovoyV. A.ТерновойВ. А.
Russian Federation

Koltsovo, Novosibirsk Region

п. Кольцово, Новосибирская обл.

ChubE. V.ЧубЕ. В.
Russian Federation

Koltsovo, Novosibirsk Region

п. Кольцово, Новосибирская обл.

PyankovS. A.ПьянковС. А.
Russian Federation

Koltsovo, Novosibirsk Region

п. Кольцово, Новосибирская обл.

AgafonovA. P.АгафоновА. П.
Russian Federation

Koltsovo, Novosibirsk Region

п. Кольцово, Новосибирская обл.

MaksyutovR. A.МаксютовР. А.
Russian Federation

Koltsovo, Novosibirsk Region

п. Кольцово, Новосибирская обл.

MaleevV. V.МалеевВ. В.
Russian Federation
PopovaA. Yu.ПоповаА. Ю.
Russian Federation

Moscow

Москва

State Research Center of Virology and Biotechnology «Vector»ГНЦ вирусологии и биотехнологии «Вектор»Central Research Institute of EpidemiologyЦентральный НИИ эпидемиологииState Institute of Occupational HealthНИИ медицины трудаFederal Service for Surveillance on Consumer Rights Protection and Human WellbeingФедеральная служба по надзору в сфере защиты прав потребителей и благополучия человекаRussian Medical Academy of Postgraduate EducationРоссийская медицинская академия последипломного образования250720189531051162508201925082019Copyright ©; 2018, Sementsova A.O., Dedkov V.G., Ternovoy V.A., Chub E.V., Pyankov S.A., Agafonov A.P., Maksyutov R.A., Maleev V.V., Popova A.Y.Copyright ©; 2018, Семенцова А.О., Дедков В.Г., Терновой В.А., Чуб Е.В., Пьянков С.А., Агафонов А.П., Максютов Р.А., Малеев В.В., Попова А.Ю.2018Sementsova A.O., Dedkov V.G., Ternovoy V.A., Chub E.V., Pyankov S.A., Agafonov A.P., Maksyutov R.A., Maleev V.V., Popova A.Y.Семенцова А.О., Дедков В.Г., Терновой В.А., Чуб Е.В., Пьянков С.А., Агафонов А.П., Максютов Р.А., Малеев В.В., Попова А.Ю.https://creativecommons.org/licenses/by/4.0https://microbiol.crie.ru/jour/article/view/421

Ebola virus disease is dangerous viral infection, occurring in the form of hemorrhagic fever, characterized by acute clinical symptoms and high mortality rate due to multiple organ failure. Ebola virus natural foci are located in forested areas of the central and western parts of Africa. It was believed for many years, the incidence of Ebola virus disease has been sporadic and the burden of it is true only in endemic areas. However, the unprecedented Ebola epidemic caused by Zaire virus in 2013 — 2016, has significantly changed our understanding of this disease and the patterns of its distribution. We have also identified weaknesses in the organization of anti-epidemic measures, the effectiveness of which was not very effective at the onset of the epidemic, in particular due to weak development of in vitro diagnostics (IVD). However, during the elimination of the epidemic in West Africa, anti-epidemic system has been modified substantially, largely due to quickly developed IVD kits. This review is devoted to analysis of trends in IVD for Ebola virus disease based on the experience obtained in the course of the West-African epidemic in 2013 — 2016.

Лихорадка Эбола — особо опасная вирусная инфекция, протекающая в виде геморрагической лихорадки, характеризующейся острым течением и высокой летальностью, обусловленной полиорганной недостаточностью и развитием инфекционно-токсического шока. Природные очаги лихорадки Эбола расположены в лесных районах центральной и западной частей Африканского континента. Долгие годы считалось, что заболеваемость лихорадкой Эбола носит спорадический характер и бремя ее актуально исключительно для эндемичных районов. Однако беспрецедентная по своим масштабам эпидемия лихорадки Эбола в 2013 — 2016 гг., вызванной вирусом Заир, существенно изменила представления о данном заболевании и о закономерностях его распространения. Во время эпидемии были выявлены слабые места в организации противоэпидемических мероприятий, эффективность которых оказалась на начальном этапе не очень высокой, в том числе и по причине отсутствия диагностических средств. Тем не менее, в ходе ликвидации эпидемии в Западной Африке система противоэпидемических мероприятий была существенно изменена, во многом благодаря оперативно разработанным средствам лабораторной диагностики. Данный обзор посвящен анализу методов и средств лабораторной диагностики лихорадки Эбола с учетом опыта, полученного в ходе эпидемии 2013 — 2016 гг. в Западной Африке.

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