Journal of microbiology, epidemiology and immunobiologyJournal of microbiology, epidemiology and immunobiologyЖурнал микробиологии, эпидемиологии и иммунобиологии0372-93112686-7613Central Research Institute for Epidemiology4010.36233/0372-9311-2016-2-119-126REVIEWSОБЗОРЫMOLECULAR BIOLOGY OF HEPATITIS B VIRUS AND IMMUNOPATHOGENESIS OF CHRONIC VIRAL HEPATITIS BМОЛЕКУЛЯРНАЯ БИОЛОГИЯ ВИРУСА ГЕПАТИТА В И ИММУНОПАТОГЕНЕЗ ХРОНИЧЕСКОГО ВИРУСНОГО ГЕПАТИТА ВBalmasovaI. P.БалмасоваИ. П.
Russian Federation
SepiashviliR. I.СепиашвилиР. И.
Russian Federation
MalovaE. S.МаловаЕ. С.
Russian Federation
Evdokimov Moscow State Medical Stomatological University, Russian University of Peoples’ FriendshipМосковский государственный медико-стоматологический университет им. А.И.Евдокимова, Российский университет дружбы народов2804201693211912610042019Copyright ©; 2016, Balmasova I.P., Sepiashvili R.I., Malova E.S.Copyright ©; 2016, Балмасова И.П., Сепиашвили Р.И., Малова Е.С.2016Balmasova I.P., Sepiashvili R.I., Malova E.S.Балмасова И.П., Сепиашвили Р.И., Малова Е.С.https://creativecommons.org/licenses/by/4.0https://microbiol.crie.ru/jour/article/view/40

Hronic hepatitis B belongs to a category of socially significant diseases due to its wide abundance in the world and high frequency of unfavourable outcomes of this disease. Features of interaction of hepatitis B virus with human immune system, accompanying development of mechanisms of escape from immunological control, is the basis of development of chronic hepatitis B. Molecular-biological features of hepatitis B virus are the basis of the indicated mechanisms, and the content of this review is their examination. Herewith, stages of immunopathogenesis of this disease is the basis of characteristics of interaction of viral proteins with cells of immune system, and isolation of those is accepted in contemporary foreign literature.

Хронический гепатит В осносится к категории социально значимых заболеваний в силу свой широкой распространенности во всем мире и высокой частоты неблагоприятных исходов этого заболевания. В основе развития хронической формы гепатита В лежат особенности взаимодействия вируса гепатита В с иммунной системой человека, сопровождающиеся развитием механизмов ускользания возбудителя от иммунологического надзора. В основе указанных механизмов лежат молекулярно-биологические особенности вируса гепатита В, рассмотрение которых входит в содержание данного обзора. При этом в основу характеристики взаимодействия вирусных белков с клетками иммунной системы положены стадии иммунопатогенеза данного заболевания, выделение которых принято в современной зарубежной литературе.

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