Journal of microbiology, epidemiology and immunobiologyJournal of microbiology, epidemiology and immunobiology0372-93112686-7613Central Research Institute for Epidemiology38210.36233/0372-9311-2019-1-59-63CLINICAL AND IMMUNOLOGICAL INFLAMMATORY PATTERNS OF BRONCHIAL ASTHMA IN OBESE PATIENTSKonischevaA. Yu.Moscowfake@neicon.ruGervazievaV. B.Moscowfake@neicon.ruMazurinaS. A.Moscowfake@neicon.ruMechnikov Research Institute of Vaccines and Sera2304201996159632208201922082019Copyright © 2019, Konischeva A.Y., Gervazieva V.B., Mazurina S.A.2019<p><strong>We aimed</strong> to investigate immunological patterns of inflammation and autoimmunity, in bronchial asthma (BA) associated with obesity. <strong>Materials and methods</strong>. 109 people aged from 17 to 58 years with various body weights have been examined in total, including 64 individuals with allergic diseases as bronchial asthma (BA) and allergic rhinitis (AR). We performed the measurement of the body mass index according to WHO criteria, and evaluation of the asthma severity and comorbid conditions. In the samples of peripheral blood we measured biochemical tests (cholesterol and its fractions), spontaneous and PHA-induced production of cytokines: IL-4, IL-10, IL-17, TNF-, and serum levels of C-reactive protein (CRP), leptin, total IgE and IgE-autoAT, specific for a number of tissue AH (epithelial keratin, collagen 3 and 6 types, elastin and myosin). <strong>Results</strong>. Our study showed that in both groups of adults, the obesity was associated with increasing of acute phase proteins, CRP, leptin and TNF-α in serum, being most enhanced in asthma group. Individuals with excess body weight are characterized by significantly an increased level of acute phase proteins (Westergren ESR, CRP) and pro-inflammatory cytokines (TNF-α) in serum, thereby confirming the involvement of systemic inflammation in the obesity pathogenesis. The phenotype of BA with obesity is characterized by overproduction of CRP and leptin, along with increased spontaneous production of IL-4 and TNF-α, and also revealed sIgE to self-antigen as keratin, that in total could indicate more prominent inflammatory pathways with the impairment of immune regulation in this endotype of patients. <strong>Conclusion</strong>. The revealed associations confirm the link between obesity, as a chronic inflammatory condition, with atopy and development of asthma with further immune-mediated inflammation of the conduction airways.</p>asthmaobesityinflammationcytokinesбронхиальная астмаожирениевоспалениецитокины[1. Астафьева Н.Г., Гамова И.В. и др. Ожирение и бронхиальная астма. Лечащий врач. 2014, 5:100-110.][2. Гервазиева В.Б., Мазурина С.А., Лысогора В.А. Аллергические заболевания у детей с повышенной массой тела и ожирением. Вопросы практической педиатрии. 2017, 12(4):54-58.][3. Гервазиева В.Б., Сверановская В.В., Конищева А.Ю. Связь аллергических заболеваний с аутоиммунитетом. Пульмонология. 2013, 6:72-78.][4. Ожирение и избыточный вес. Информационный бюллетень ВОЗ. 2016, июнь, №311.][5. Beuther D.A., Sutherland E.R. Overweight, obesity, and incident asthma: a meta-analysis of prospective epidemiologic studies. Am. J. Respir. Crit. Care Med. 2007, 175: 661-666.][6. Camargo C.A. Jr., Weiss S.T., Zhang S. et al. Prospective study of body mass index, weight change, and risk of adult-onset astma in women. Arch. Intern. Med. 1999, 159:2582-2588.][7. Flaherman V.1., Rutherford G.W. A meta-analysis of the effect of high weight on asthma. Arch. Dis. Child. 2006. 91(4):334-339.][8. Global Strategy for Asthma Management and Prevention (updated 2016). Available from: www.ginasthma.org.][9. Gibson P.G. Obesity and asthma. Ann. Am. Thorac. Soc. 2013; 10: 138-142. doi: 10.1513/AnnalsATS.201302-038AW.][10. Mosen D.M., Schatz M., Magid D.J., Camargo C.A. Jr. The relationship between obesity and astma severity and control in adults. J. Allergy Clin. Immunol. 2008; 122: 507-511.][11. Novosad S., Khan S., Wolfe B., Khan A. Role of obesity in asthma control, the obesity- asthma phenotype. J. Allergy. 2013; 2013:538642.][12. Sood A., Shore S.A. Adiponectin, leptin, and resistin in asthma: basic mechanisms through population studies. J. Allergy. 2013; 2013: Article ID 785835.][13. Sutherland E.R., Goleva E., Strand M. et al. Body mass and glucocorticoid response in asthma. Am. J. Respir. Crit. Care Med. 2008, 178(7): 682-687.][14. Vortmann M., Eisner M.D. BMI and health status among adults with asthma. Obesity (Silver Spring). 2008. 16(1): 146-152. doi: 10.1038/oby.2007.7.][15. Wajchenberg B.L., Giannella-Neto D. Depot-specific hormonal characteristics of subcutaneous and visceral adipose tissue and their relation to the metabolic syndrome. Horm. Metab. Res. 2002. 34(11-12): 616-621.]