Journal of microbiology, epidemiology and immunobiologyJournal of microbiology, epidemiology and immunobiology0372-93112686-7613Central Research Institute for Epidemiology37910.36233/0372-9311-2019-2-30-36UnknownEpidemiological and molecular-genetic monitoring of rotavirus infection in the Orenburg region in the period predictivelyAkimkinV. G.Moscow.fake@neicon.ruGorelovA. V.Moscow.fake@neicon.ruPodkolzinA. T.Moscow.fake@neicon.ruDenisyukN. B.<p class="MsoNormal"><span style="font-size: 14.0pt; line-height: 107%; mso-ansi-language: EN-US;" lang="EN-US">Orenburg</span><span style="font-size: 14.0pt; line-height: 107%;">.</span></p>fake@neicon.ruCentral Research Institute of EpidemiologyOrenburg State Medical University2207201996230362208201922082019Copyright © 2019, Akimkin V.G., Gorelov A.V., Podkolzin A.T., Denisyuk N.B.2019<p class="MsoNormal"><span lang="EN-US" style="font-size: 14.0pt; line-height: 107%; mso-ansi-language: EN-US;">Aim. To analyze the epidemiological situation of rotavirus infection in the Orenburg region, taking into account the manifestations of the epidemic process and the molecular genetic characteristics of rotavirus group. Materials and methods. We </span><span style="font-size: 14.0pt; line-height: 107%;">р</span><span lang="EN-US" style="font-size: 14.0pt; line-height: 107%; mso-ansi-language: EN-US;">resented the results of epidemiological and molecular genetic monitoring of rotavirus infection in the period 2013-2017. Molecular genetic typing was performed in 232 fecal samples of patients under 3 years of age with rotavirus infection. Were used methods of retrospective epidemiological analysis, ELISA, PCR. Results. The incidence of high tear and had a tendency to increase. The most affected were children under 14 years of age. The genetic potential of the rotavirus population in the region was represented by ten main genotypes. The leading significance in the epidemic process were genotypes with the highest frequency of occurrence: G4[P]8 (56,9%), G9[P]8 (12,9%), Mixt (8,6%), G2[P]4 (7,7%), G1[P]8 (6,5%). Conclusion. Were revealed a significant increase in the incidence of rotavirus infection among children. Were revealed the dominant genotypes of rotaviruses, their regional diversity and change during several seasons.</span></p>genotypeschildrenmorbidityrotavirus infectionгенотипыдетизаболеваемостьротавирусная инфекция[1. Духовлинов И.В., Богомолова Е.Г., Федорова Е.А., Симбирцев А.С. Генетические и антигенные варианты ротавируса человека, циркулирующие на Европейской территории России. Инфекция и иммунитет.2014, 4(3):229-234.][2. Жираковская, Е.В., Аксанова Р.Х, Горбунова М.Г. и др. Генетическое разнообразие изолятов ротавирусов группы А, выявленных в Западной Сибири в 2007-2011 гг. Молекулярная генетика, микробиология и вирусология.2012, 4:33-41.][3. Зайцева Е.В., Ольнева Т.А., Кулешов К.В., Подколзин А.Т., Шипулин Г.А. и др. Результаты мониторинга антигенных типов ротавирусов гр.А на территории Российской Федерации в период 2011-2015 гг. Клиническая лабораторная диагностика. 2016, 61(7) 445-448.][4. Кригер Е.А., Самодова О.В., Назаренко С.Ю. Внутрибольничная ротавирусная инфекция у детей. Инфекционные болезни. 2013, 11(3):62-65.][5. Литвинчук О.А., Коновалова Т.А., Подколзин А.Т., Горелов А.В., Шипулин Г.А. Нозокомиальные кишечные инфекции в инфекционных отделениях детских стационаров. Молекулярная диагностика. 2014, 2(12):413-415.][6. Плоскирева А.А. Острые кишечные инфекции вирусной этиологии у детей: клиника, диагностика и терапия. Автореферат дисс. докт. мед. наук. М, 2016.][7. Подколзин А.Т. Эпидемиологическая и клиническая характеристика острых кишечных инфекций вирусной этиологии в Российской Федерации. Автореф. дисс. докт. мед. наук. М., 2015.][8. Lanata C.F. Child Health Epidemiology Reference Group of the World Health Organization and UNICEF Global causes of diarrheal disease mortality in children younger 5 years of age: a systematic review. PLoS One. 2013, 8(9): e72788.][9. Lozano R., Naghavi M., Foreman K. Global and regional mortality from 235 causes of death for 20 age groups in 1990 and 2010: a systematic analysis for the Global Burden of Disease Study 2010. Lancet.2013;380(9859):2095-2128.][10. Мandal S., Mandal M.D. Is Rotavirus Gastroenteritis a Global Emerging. Re-Emerg Probl. Transl. Med. 2014, 4(143):2161-1025.][11. Parashar U.D., Gibson C.J., Bresee J.S. et al. Rotavirus and severe childhood diarrhea. Emerg.Infect. Dis. 2006, 12:304-306.][12. Vesicari T., Hemming M., Huhti L. et al. Rotavirus antigenemia in children is associated with more severe clinical manifestations of acute gastroenteritis. Pediatr. Infect. Dis. J. 2014, 33(4):366-371.]