Journal of microbiology, epidemiology and immunobiologyJournal of microbiology, epidemiology and immunobiologyЖурнал микробиологии, эпидемиологии и иммунобиологии0372-93112686-7613Central Research Institute for Epidemiology37110.36233/0372-9311-2019-3-83-91REVIEWSОБЗОРЫBiohazard caused by viable but nonculturable microorganismsБиоопасность жизнеспособных некультивируемых микроорганизмовPakhomovYu. D.ПахомовЮ. Д.
Russian Federation

Moscow

Пахомов Юрий Дмитриевич - кандидат биологических наук.

105064, Москва, М.Казенный пер., 5а, р.т. (495)916-11-52

BlinkovaL. P.БлинковаЛ. П.
Russian Federation

Moscow

Москва

Mechnikov Research Institute of Vaccines and SeraНИИ вакцин и сывороток им. И.И. Мечникова2208201996383912108201921082019Copyright ©; 2019, Pakhomov Y.D., Blinkova L.P.Copyright ©; 2019, Пахомов Ю.Д., Блинкова Л.П.2019Pakhomov Y.D., Blinkova L.P.Пахомов Ю.Д., Блинкова Л.П.https://creativecommons.org/licenses/by/4.0https://microbiol.crie.ru/jour/article/view/371

In this review we discuss current notions about viable but nonculturable microorganisms — new subject of microbiological research. Information about factors and conditions of formation of nonculturable cells and their resuscitation is analyzed. Of particular interest is information of biohazard of nonculturable cells that are hard to isolate by traditional means from organisms, the environment, foodstuffs etc. Knowledge about this is valuable for detection live microbes from clinical samples, levels of viable but nonculturable cells in vaccine and probiotic preparations, culture collections.

В обзоре изложены современные представления о жизнеспособных некультивируемых микроорганизмах — новом направлении исследований в общей и медицинской микробиологии. Анализируется информация о факторах и условиях перехода в некультивируемое состояние и выхода из него. Особый интерес представляют сведения о биоопасности жизнеспособных некультивируемых патогенов, трудно выделяемых рутинными методами в организме, окружающей среде, продуктах питания и т.д. Знания об этом явлении ценны для детекции живых микробов при изучении клинических образцов, уровня жизнеспособных некультивируемых клеток в препаратах вакцин, пробиотиков, музейных культур и др.

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