Journal of microbiology, epidemiology and immunobiologyJournal of microbiology, epidemiology and immunobiologyЖурнал микробиологии, эпидемиологии и иммунобиологии0372-93112686-7613Central Research Institute for Epidemiology28910.36233/0372-9311-2018-4-68-76ИНФЕКТОЛОГИЧЕСКИЕ МЕХАНИЗМЫ СИМБИОТИЧЕСКИХ ВЗАИМОДЕЙСТВИЙMOLECULAR MECHANISMS OF BRUCELLA PERSISTENCEМОЛЕКУЛЯРНЫЕ МЕХАНИЗМЫ ПЕРСИСТЕНЦИИ ВОЗБУДИТЕЛЯ БРУЦЕЛЛЕЗАKulakovYu. K.КулаковЮ. К.
Russian Federation
Gamaleya National Research Centre of Epidemiology and MicrobiologyНациональный исследовательский центр эпидемиологии и микробиологии им. Н.Ф. Гамалеи28082018954687610042019Copyright ©; 2018, Kulakov Y.K.Copyright ©; 2018, Кулаков Ю.К.2018Kulakov Y.K.Кулаков Ю.К.https://creativecommons.org/licenses/by/4.0https://microbiol.crie.ru/jour/article/view/289

Brucellosis is an infectious, especially dangerous zoonotic disease of agricultural and wild animals, from which it is transmitted to humans and characterized by a chronic course with disability of working-age patients. Bacteria of the genus Brucella are facultative intracellular pathogens capable of multiplying and persisting in the host’s immune cells with the development of chronic infection. The host-specific evolutionary mechanisms allow Brucella to hide and manipulate the systems of innate and acquired cellular immunity to achieve intracellular persistence. The review describes the molecular mechanisms that ensure the persistence of the causative agent of brucellosis. The evolution of Brucella species is associated with the adaptation of intracellular preservation and persistence in the formed granulomatous structures. Understanding the molecular mechanisms of Brucella persistence should be considered in programs for its control and elimination, and also allows the development of new effective tools for the prevention and treatment of brucellosis.

Бруцеллез - инфекционное, особо опасное зоонозное заболевание сельскохозяйственных и диких животных, от которых передается человеку и характеризуется хроническим течением с инвалидизацией больных трудоспособного возраста. Бактерии рода Brucella - факультативные внутриклеточные патогены, способные размножаться и персистировать в иммунных клетках хозяина с развитием хронической инфекции. Хозяйско-специфичные эволюционные механизмы позволяют бруцеллам скрываться и манипулировать системами врожденного и приобретенного клеточного иммунитета для достижения внутриклеточной персистенции. В обзоре показаны молекулярные механизмы, обеспечивающие персистенцию возбудителя бруцеллеза. Эволюция бруцелл связана с адаптацией внутриклеточного сохранения и персистенции в сформированных гранулематозных структурах. Понимание молекулярных механизмов персистенции возбудителя бруцеллеза следует учитывать в программах по его контролю и элиминации и позволяет разрабатывать новые эффективные средства для профилактики и лечения бруцеллеза.

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