Journal of microbiology, epidemiology and immunobiologyJournal of microbiology, epidemiology and immunobiologyЖурнал микробиологии, эпидемиологии и иммунобиологии0372-93112686-7613Central Research Institute for Epidemiology1920810.36233/0372-9311-780ZLBKXLORIGINAL RESEARCHESОРИГИНАЛЬНЫЕ ИССЛЕДОВАНИЯResearch ArticleVirucidal efficacy of compositions based on lanthanum nitrate hexahydrateВирулицидная эффективность композиций на основе гексагидрата нитрата лантанаhttps://orcid.org/0000-0002-1551-718XBerezhnayaElena V.БережнаяЕлена Викторовна
Russian Federation

junior researcher, Laboratory of antivirals and disinfectants, D.I. Ivanovsky Institute of virology

м. н. с. лаб. противовирусных и дезинфекционных средств Института вирусологии им. Д.И. Ивановского

elvenel@gmail.comhttps://orcid.org/0000-0002-5315-6370PashkinIgor I.ПашкинИгорь Иванович
Russian Federation

Cand. Sci. (Chem.), main specialist, S.S. Medvedev Department of chemistry and technology of macromolecular compounds, M.V. Lomonosov Institute of Fine Chemical Technologies

канд. хим. наук, главный специалист, каф. химии и технологии высокомолекулярных соединений им. С.С. Медведева Института тонких химических технологий им. М.В. Ломоносова

pashkin@mirea.ruhttps://orcid.org/0000-0001-9295-8379BochkovaMarina S.БочковаМарина Сергеевна
Russian Federation

leading researcher, Laboratory of antivirals and disinfectants, D.I. Ivanovsky Institute of Virology

в. н. с. лаб. противовирусных и дезинфекционных средств Института вирусологии им. Д.И. Ивановского

bochkovams1@yandex.ruhttps://orcid.org/0000-0003-3985-3839KondrashinaNina G.КондрашинаНина Геннадьевна
Russian Federation

leading researcher, Laboratory of antivirals and disinfectants, D.I. Ivanovsky Institute of Virology

в. н. с. лаб. противовирусных и дезинфекционных средств Института вирусологии им. Д.И. Ивановского

nina.kond1950@yandex.ruhttps://orcid.org/0000-0003-4458-8013KuzmichevaGalina M.КузьмичеваГалина Михайловна
Russian Federation

Dr. Sci. (Chem.), Professor, Department of materials engineering, Advanced Engineering School of Microwave Electronics, Director, Scientific and Educational Center “Multiscale Design of Materials”

д-р хим. наук, профессор, каф. инженерии материалов Передовой инженерной школы СВЧ-электроники, директор научно-образовательного центра «Многомасштабное конструирование материалов»

galina_kuzmicheva@list.ruhttps://orcid.org/0000-0001-6082-7331DomoroshchinaElena N.ДоморощинаЕлена Николаевна
Russian Federation

Cand. Sci. (Chem.), Head, Specialized educational and scientific laboratory “Functional materials and nanostructures”, Scientific and Educational Center “Multiscale Design of Materials”

канд. хим. наук, зав. специализированной учебно-научной лабораторией «Функциональные материалы и наноструктуры» Научно-образовательного центра «Многомасштабное конструирование материалов»

elena_domoroshchina@mail.ruhttps://orcid.org/0000-0001-5757-5671NosikDmitry N.НосикДмитрий Николаевич
Russian Federation

Dr. Sci. (Med.), Professor, Head, Laboratory of antiviral and disinfection agents, D.I. Ivanovsky Institute of Virology

д-р мед. наук, профессор, зав. лаб. противовирусных и дезинфекционных средств Института вирусологии им. Д.И. Ивановского

dnnosik@yandex.ruNational Research Center of Epidemiology and Microbiology named after honorary academician N.F. GamaleyaФГБУ «Национальный исследовательский центр эпидемиологии и микробиологии имени почётного академика Н.Ф. Гамалеи» Минздрава РоссииMIREA — Russian Technological UniversityФГБОУ ВО «МИРЭА — Российский технологический университет»1207202610333793851207202612072026Copyright ©; 2026, Berezhnaya E.V., Pashkin I.I., Bochkova M.S., Kondrashina N.G., Kuzmicheva G.M., Domoroshchina E.N., Nosik D.N.Copyright ©; 2026, Бережная Е.В., Пашкин И.И., Бочкова М.С., Кондрашина Н.Г., Кузьмичева Г.М., Доморощина Е.Н., Носик Д.Н.2026Berezhnaya E.V., Pashkin I.I., Bochkova M.S., Kondrashina N.G., Kuzmicheva G.M., Domoroshchina E.N., Nosik D.N.Бережная Е.В., Пашкин И.И., Бочкова М.С., Кондрашина Н.Г., Кузьмичева Г.М., Доморощина Е.Н., Носик Д.Н.https://creativecommons.org/licenses/by/4.0/https://microbiol.crie.ru/jour/article/view/19208

Background. The most urgent problem of medicine is the fight against viral diseases. Preventive measures in the form of antiseptics with virucidal effect (VE) play an important role. Antimicrobial properties have been noted in compounds based on rare-earth metals.

The aim of the study was to investigate the VE of lanthanum nitrate hexahydrate (LNH) and compositions based on it in order to establish the possibility of using them in the composition of topical antiseptics.

Materials and methods. The VE of compounds was studied on the model of viruses: poliovirus, adenovirus, human immunodeficiency virus (HIV-1), herpes simplex virus (HSV-1). The VE was assessed by degree of reduction of virus titer in lg TCID50. The following compounds were studied: organic lanthanum composition (OLC), consisting of LNH (La(NO3)3·6H2O), triethylene glycol (TEG), ethyl carbitol (EC), glycerol, H2O and NaOH, as well as solutions of LNH in H2O and glycols: TEG, EC, 1,2-propylene glycol (PG), 1,3-butylene glycol (BG), polyethylene glycol-400 (PEG) and glycols themselves.

Results. OLC reduced titers of poliovirus and adenovirus by 4.0-4.5 lg TCID50 in vitro, on surfaces by 4.0–5.0 lg TCID50 with disinfection time of 1–2 minutes. Components included in OLC reduced the titer of poliovirus by 3.1-4.0 lg TCID50. The reduction of HSV-1 titer of all compounds amounted to 4.0–4.3 lg TCID50. La(NO3)3·6H2O in PG, BG, PEG-400 and EC reduced HIV-1 titer by 4.8–5.3 lg TCID50 at pH below 4.62. The VE of LNH on HIV-1 on the surface is the reduction of the titer by 2.3–3.3 lg TCID50, depending on disinfection duration, the HSV-1 reduction titer amounted to 3.8 lg TCID50.

Conclusion. For the first time it has been established that LNH and OLC possess a virucidal effect against both enveloped and non-enveloped viruses and can be considered as components of virucidal antiseptics. The VE of LNH without participation of additional compounds is very promising.

Background. The most urgent problem of medicine is the fight against viral diseases. Preventive measures in the form of antiseptics with virucidal effect (VE) play an important role. Antimicrobial properties have been noted in compounds based on rare-earth metals.

The aim of the study was to investigate the VE of lanthanum nitrate hexahydrate (LNH) and compositions based on it in order to establish the possibility of using them in the composition of topical antiseptics.

Materials and methods. The VE of compounds was studied on the model of viruses: poliovirus, adenovirus, human immunodeficiency virus (HIV-1), herpes simplex virus (HSV-1). The VE was assessed by degree of reduction of virus titer in lg TCID50. The following compounds were studied: organic lanthanum composition (OLC), consisting of LNH (La(NO3)3·6H2O), triethylene glycol (TEG), ethyl carbitol (EC), glycerol, H2O and NaOH, as well as solutions of LNH in H2O and glycols: TEG, EC, 1,2-propylene glycol (PG), 1,3-butylene glycol (BG), polyethylene glycol-400 (PEG) and glycols themselves.

Results. OLC reduced titers of poliovirus and adenovirus by 4.0-4.5 lg TCID50 in vitro, on surfaces by 4.0–5.0 lg TCID50 with disinfection time of 1–2 minutes. Components included in OLC reduced the titer of poliovirus by 3.1-4.0 lg TCID50. The reduction of HSV-1 titer of all compounds amounted to 4.0–4.3 lg TCID50. La(NO3)3·6H2O in PG, BG, PEG-400 and EC reduced HIV-1 titer by 4.8–5.3 lg TCID50 at pH below 4.62. The VE of LNH on HIV-1 on the surface is the reduction of the titer by 2.3–3.3 lg TCID50, depending on disinfection duration, the HSV-1 reduction titer amounted to 3.8 lg TCID50.

Conclusion. For the first time it has been established that LNH and OLC possess a virucidal effect against both enveloped and non-enveloped viruses and can be considered as components of virucidal antiseptics. The VE of LNH without participation of additional compounds is very promising.

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