Journal of microbiology, epidemiology and immunobiologyJournal of microbiology, epidemiology and immunobiologyЖурнал микробиологии, эпидемиологии и иммунобиологии0372-93112686-7613Central Research Institute for Epidemiology1907710.36233/0372-9311-787KVRAXWREVIEWSОБЗОРЫReview ArticleKey factors of pathogenicity of Enterobacter spp.Ключевые факторы патогенности Enterobacter spp.https://orcid.org/0000-0002-9991-6750KokorevDaniil A.КокоревДаниил Андреевич
Russian Federation

junior researcher, Laboratory of genetic technologies in microbiology, Professional Center for Education and Research in Genetic and Laboratory Technologies, assistant professor, Chair of medical microbiology and immunology

м. н. с. лаб. генетических технологий в микробиологии Научно-образовательного профессионального центра генетических и лабораторных технологий, ассистент каф. медицинской микробиологии и иммунологии

d.a.kokorev@samsmu.ruhttps://orcid.org/0009-0000-1954-9245StrazhinaEkaterina A.СтражинаЕкатерина Александровна
Russian Federation

specialist, Laboratory of educational technologies in genetics, microbiology and laboratory diagnostics, Professional Center for Education and Research in Genetic and Laboratory Technologies

специалист лаб. образовательных технологий в генетике, микробиологии и лабораторной диагностике Научно-образовательного профессионального центра генетических и лабораторных технологий

e.a.strazhina@samsmu.ruhttps://orcid.org/0000-0002-5905-1895LyaminArtem V.ЛяминАртем Викторович
Russian Federation

Dr. Sci. (Med.), Associate Professor, Director, Professional Center for Education and Research in Genetic and Laboratory Technologies, Professor, Chair of medical microbiology and immunology

д-р мед. наук, доцент, директор Научно-образовательного профессионального центра генетических и лабораторных технологий, профессор кафедры медицинской микробиологии и иммунологии

a.v.lyamin@samsmu.ruSamara State Medical UniversityФГБОУ ВО «Самарский государственный медицинский университет» Минздрава России1303202610311371521303202613032026Copyright ©; 2026, Kokorev D.A., Strazhina E.A., Lyamin A.V.Copyright ©; 2026, Кокорев Д.А., Стражина Е.А., Лямин А.В.2026Kokorev D.A., Strazhina E.A., Lyamin A.V.Кокорев Д.А., Стражина Е.А., Лямин А.В.https://creativecommons.org/licenses/by/4.0https://microbiol.crie.ru/jour/article/view/19077

The review presents current literature data on the main pathogenicity factors of Enterobacter spp., which ensure the colonization of various human ecological niches and the ability to develop an infectious process. The relevance of Enterobacter spp. is associated with their ability to cause nosocomial infections, especially in immunocompromised patients. The combination of pathogenicity factors provides the opportunity of shielding from the host body's defense mechanisms, which is necessary for the persistence of Enterobacter spp. The analysis of the literature data allowed us to determine the pathogenicity factors of Enterobacter spp., which make the greatest contribution to the development of the infectious process. The identification and study of key pathogenicity factors creates the basis for the development of new diagnostic methods and strategies for personalized therapy of Enterobacter spp. infections.

The purpose of the review is to summarize data on the pathogenicity factors of Enterobacter spp. and their role in the development of the infectious process in humans.

The analysis of literature data on the virulence factors of Enterobacteriaceae, particularly microorganisms of the Enterobacter spp., is conducted. The search and selection of literature were carried out using bibliographic databases, such as PubMed, Google Scholar, and the scientific electronic library Elibrary. The search queries included the following keywords, used individually or in various combinations: «Enterobacteriaceae», «Enterobacter spp.», «pathogenicity factors», «virulence factors», «persistence factors», «siderophores», «toxins», «adhesins», «capsule», «flagella», «Curli fibers», «secretion systems», «biofilm». In addition to keyword searches, the review included articles found through citation analysis within publications, as well as manually selected publications. This review includes articles published between 2002 and 2025.

В обзоре представлены современные данные литературы об основных факторах патогенности представителей семейства Enterobacteriaceae, в частности Enterobacter spp., обеспечивающих колонизацию различных экологических ниш человека и способность к развитию инфекционного процесса. Актуальность Enterobacter spp. связана с их способностью вызывать нозокомиальные инфекции, особенно у иммунокомпрометированных пациентов. Совокупность факторов патогенности обеспечивает возможность экранирования от защитных механизмов организма хозяина, что необходимо для персистенции Enterobacter spp. Анализ данных позволил определить факторы патогенности представителей рода Enterobacter, которые вносят наибольший вклад в развитие инфекционного процесса. Выявление и изучение ключевых факторов патогенности создаёт основу для разработки новых методов диагностики и стратегий персонифицированной терапии инфекций, вызванных Enterobacter spp.

Целью обзора является обобщение данных о факторах патогенности Enterobacter spp. и их роли в развитии инфекционного процесса у человека.

Поиск и подбор литературы осуществляли с использованием библиографических баз данных PubMed, Google Scholar, eLIBRARY.RU. Поисковые запросы включали по отдельности или в различных комбинациях ключевые слова: «Enterobacteriaceae», «Enterobacter spp.», «факторы патогенности», «факторы вирулентности», «факторы персистенции», «сидерофоры», «токсины», «адгезины», «капсула», «жгутики», «волокна Curli», «системы секреции», «биоплёнка». Помимо запросов по ключевым словам, в обзор были включены статьи, найденные с помощью анализа цитирования в тексте публикаций, а также публикации, отобранные вручную. В данный обзор включены статьи, опубликованные в 2002–2025 гг.

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