Journal of microbiology, epidemiology and immunobiologyJournal of microbiology, epidemiology and immunobiologyЖурнал микробиологии, эпидемиологии и иммунобиологии0372-93112686-7613Central Research Institute for Epidemiology1862110.36233/0372-9311-486iwenhgREVIEWSОБЗОРЫReview ArticleMonoclonal antibody techniques. 50 years of developmentТехнология получения моноклональных антител. 50 лет развитияhttps://orcid.org/0000-0002-1165-2712MassinoYulia S.МассиноЮлия Сергеевна
Russian Federation

Cand. Sci. (Biol.), senior researcher, Laboratory of diagnostics of viral infections, Department of virology

к.б.н., с.н.с. лаб. диагностики вирусных инфекций отдела вирусологии

ytarakanova@mail.ruhttps://orcid.org/0000-0003-3226-5989TarakanovaYulia N.ТаракановаЮлия Николаевна
Russian Federation

Cand. Sci. (Biol.), Head, Laboratory of diagnostics of viral infections, Department of virology

к.б.н., зав. лаб. диагностики вирусных инфекций отдела вирусологии

ytarakanova@mail.ruhttps://orcid.org/0000-0002-6621-236XSegalOlga L.СегалОльга Леонидовна
Russian Federation

Cand. Sci. (Biol.), senior researcher, Laboratory of diagnostics of viral infections, Department of virology

к.б.н., с.н.с. лаб. диагностики вирусных инфекций отдела вирусологии

ytarakanova@mail.ruhttps://orcid.org/0000-0002-6628-1576PechelyulkoAnastasia A.ПечелюлькоАнастасия Александровна
Russian Federation

researcher, Laboratory of diagnostics of viral infections, Department of virology

н.с. лаб. диагностики вирусных инфекций отдела вирусологии

ytarakanova@mail.ruhttps://orcid.org/0000-0001-8771-4177YakovlevaDinora A.ЯковлеваДинора Абдуллаевна
Russian Federation

Cand. Sci. (Med.), senior researcher, Laboratory of diagnostics of viral infections, Department of virology

к.м.н., с.н.с. лаб. диагностики вирусных инфекций отдела вирусологии

ytarakanova@mail.ruhttps://orcid.org/0000-0001-9579-7865LichutinaMaria V.ЛичутинаМария Владимировна
Russian Federation

junior researcher, Laboratory of diagnostics of viral infections, Department of virology

м.н.с. лаб. диагностики вирусных инфекций отдела вирусологии

ytarakanova@mail.ruhttps://orcid.org/0000-0002-7397-6499DmitrievDmitriy A.ДмитриевДмитрий Александрович
Russian Federation

Cand. Sci. (Biol.), senior researcher, Laboratory of diagnostics of viral infections, Department of virology

к.б.н., с.н.с. лаб. диагностики вирусных инфекций отдела вирусологии

ytarakanova@mail.ruhttps://orcid.org/0000-0002-1132-3708DmitrievAlexander D.ДмитриевАлександр Дмитриевич
Russian Federation

D. Sci. (Biol.), leading researcher, Laboratory of diagnostics of viral infections, Department of virology

д.б.н., в.н.с. лаб. диагностики вирусных инфекций отдела вирусологии

ytarakanova@mail.ruI. Mechnikov Research Institute for Vaccines and SeraНаучно-исследовательский институт вакцин и сывороток имени И.И. Мечникова1607202410134124271607202416072024Copyright ©; 2024, Massino Y.S., Tarakanova Y.N., Segal O.L., Pechelyulko A.A., Yakovleva D.A., Lichutina M.V., Dmitriev D.A., Dmitriev A.D.Copyright ©; 2024, Массино Ю.С., Тараканова Ю.Н., Сегал О.Л., Печелюлько А.А., Яковлева Д.А., Личутина М.В., Дмитриев Д.А., Дмитриев А.Д.2024Massino Y.S., Tarakanova Y.N., Segal O.L., Pechelyulko A.A., Yakovleva D.A., Lichutina M.V., Dmitriev D.A., Dmitriev A.D.Массино Ю.С., Тараканова Ю.Н., Сегал О.Л., Печелюлько А.А., Яковлева Д.А., Личутина М.В., Дмитриев Д.А., Дмитриев А.Д.https://creativecommons.org/licenses/by/4.0https://microbiol.crie.ru/jour/article/view/18621

Monoclonal antibodies are widely used in all fields of biology and medicine. The emergence and development of the technology for their production revolutionized immunology and allowed the creation of not only new diagnostic methods, but also many effective drugs. The purpose of our review is to analyze and summarize relevant data concerning the technology of obtaining monoclonal antibodies. We have analyzed information from 70 modern literary sources devoted to various methods of obtaining them. In this review, we tried to cover the entire range of methods used to obtain monoclonal antibodies today.

Моноклональные антитела широко используются во всех областях биологии и медицины. Появление и развитие технологии их получения произвело революцию в иммунологии и позволило создать не только новые методы диагностики, но и множество эффективных лекарственных препаратов. Целью нашего обзора стали анализ и обобщение актуальных данных, затрагивающих технологию получения моноклональных антител. Нами проведён анализ информации из 70 современных источников литературы, посвящённых различным методам их получения, в том числе классической гибридомной технологии. В настоящей работе мы попытались охватить весь спектр методов, используемых для получения моноклональных антител.

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