Journal of microbiology, epidemiology and immunobiologyJournal of microbiology, epidemiology and immunobiologyЖурнал микробиологии, эпидемиологии и иммунобиологии0372-93112686-7613Central Research Institute for Epidemiology18410.36233/0372-9311-2017-4-91-100REVIEWSОБЗОРЫINTERACTION OF SALMONELLA WITH HOST ORGANISMВЗАИМОДЕЙСТВИЕ сальмонелл с организмом хозяинаBoichenkoM. N.БойченкоМ. Н.
Russian Federation
ZverevV. V.ЗверевВ. В.
Russian Federation
VolchkovaE. V.ВолчковаЕ. В.
Russian Federation
Sechenov First Moscow State Medical UniversityПервый московский государственный медицинский университет им. И.М.Сеченова280820179449110010042019Copyright ©; 2017, Boichenko M.N., Zverev V.V., Volchkova E.V.Copyright ©; 2017, Бойченко М.Н., Зверев В.В., Волчкова Е.В.2017Boichenko M.N., Zverev V.V., Volchkova E.V.Бойченко М.Н., Зверев В.В., Волчкова Е.В.https://creativecommons.org/licenses/by/4.0https://microbiol.crie.ru/jour/article/view/184

Diseases caused by Salmonella enterica species bacteria remain a healthcare challenge. Salmonella enterica species is divided into typhoid serovars that cause systemic infection and non-typhoid serovars that most frequently have a course of gastroenteritis with a development of inflammatory diarrhea. Both types of salmonella are opportunistic intracellular parasites able to invade and reproduce in both professional and non-professional phagocytes, e.g. M- cells and enterocytes. Invasion of cells and reproduction in them relates to functioning of salmonella pathogenicity island genes that determined synthesis of the third type of secretory system (T3SS). Contrary to the salmonella typhoid group serovars, non-typhoid serovars cause a development of inflammatory diarrhea, and effector molecules of T3SS as well as innate immunity components take part in it.

Заболевания, вызванные бактериями вида Salmonella enterica, остаются актуальной проблемой здравоохранения. Вид Salmonella enterica подразделяется на тифоидные серовары, которые вызывают системную инфекцию, и нетифоидные серовары, которые чаше всего протекают в форме гастроэнтерита с развитием воспалительной диареи. Оба типа сальмонелл являются факультативными внутриклеточными паразитами, способными инвазировать и размножаться как в профессиональных, так и в непрофессиональных фагоцитах, таких как М-клетка и энтероциты. Инвазия клеток и размножение в них связано с функционированием генов сальмонеллезных островов патогенности, которые определяют синтез третьего типа секреторных систем (ТЗСС). В отличие от серорваров сальмонелл тифоидной группы, нетифоидные серовары вызывают развитие воспалительной диареи, в развитии которой принимают участие как эффекторные молекулы ТЗСС, так и компоненты врожденного иммунитета. Рассматриваются новые подходы к лечению заболеваний, вызванных сальмонеллами через блокирование ТЗСС.

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