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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="other" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Journal of microbiology, epidemiology and immunobiology</journal-id><journal-title-group><journal-title xml:lang="en">Journal of microbiology, epidemiology and immunobiology</journal-title><trans-title-group xml:lang="ru"><trans-title>Журнал микробиологии, эпидемиологии и иммунобиологии</trans-title></trans-title-group></journal-title-group><issn publication-format="print">0372-9311</issn><issn publication-format="electronic">2686-7613</issn><publisher><publisher-name xml:lang="en">Central Research Institute for Epidemiology</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">167</article-id><article-id pub-id-type="doi">10.36233/0372-9311-2017-3-99-106</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>ORIGINAL RESEARCHES</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>ОРИГИНАЛЬНЫЕ ИССЛЕДОВАНИЯ</subject></subj-group><subj-group subj-group-type="article-type"><subject></subject></subj-group></article-categories><title-group><article-title xml:lang="en">FREQUENCY OF DETECTION OF ANTIBODIES TO HEPATITIS C VIRUS AMONG CONVENTIONALLY HEALTHY POPULATION OF RUSSIAN FEDERATION</article-title><trans-title-group xml:lang="ru"><trans-title>ЧАСТОТА ВЫЯВЛЕНИЯ АНТИТЕЛ К ВИРУСУ ГЕПАТИТА С СРЕДИ УСЛОВНО ЗДОРОВОГО НАСЕЛЕНИЯ РОССИЙСКОЙ ФЕДЕРАЦИИ</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Soboleva</surname><given-names>N. V.</given-names></name><name xml:lang="ru"><surname>Соболева</surname><given-names>И. В.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Karlsen</surname><given-names>A. A.</given-names></name><name xml:lang="ru"><surname>Карлсен</surname><given-names>А. А.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><xref ref-type="aff" rid="aff2"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Kozhanova</surname><given-names>T. V.</given-names></name><name xml:lang="ru"><surname>Кожанова</surname><given-names>Т. В.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><xref ref-type="aff" rid="aff3"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Kichatova</surname><given-names>V. S.</given-names></name><name xml:lang="ru"><surname>Кичатова</surname><given-names>В. С.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><xref ref-type="aff" rid="aff2"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Klushkina</surname><given-names>V. V.</given-names></name><name xml:lang="ru"><surname>Клушкина</surname><given-names>В. В.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><xref ref-type="aff" rid="aff4"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Isaeva</surname><given-names>O. V.</given-names></name><name xml:lang="ru"><surname>Исаева</surname><given-names>О. В.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><xref ref-type="aff" rid="aff2"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Ignatyeva</surname><given-names>M. E.</given-names></name><name xml:lang="ru"><surname>Игнатьева</surname><given-names>М. Е.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><xref ref-type="aff" rid="aff5"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Romanenko</surname><given-names>VV. ..</given-names></name><name xml:lang="ru"><surname>Романенко</surname><given-names>В. В.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><xref ref-type="aff" rid="aff6"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Oorzhak</surname><given-names>N. D.</given-names></name><name xml:lang="ru"><surname>Ооржак</surname><given-names>Н. Д.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><xref ref-type="aff" rid="aff7"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Malinnikova</surname><given-names>E. Yu.</given-names></name><name xml:lang="ru"><surname>Малинникова</surname><given-names>Е. Ю.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><xref ref-type="aff" rid="aff2"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Kyuregyan</surname><given-names>K. K.</given-names></name><name xml:lang="ru"><surname>Кюрегян</surname><given-names>К. К.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><xref ref-type="aff" rid="aff2"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Mikhaylov</surname><given-names>M. I.</given-names></name><name xml:lang="ru"><surname>Михайлов</surname><given-names>М. И.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><xref ref-type="aff" rid="aff2"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">Chumakov Institute of Poliomyelitis and Viral Encephalitides</institution></aff><aff><institution xml:lang="ru">Институт полиомиелита и вирусных энцефалитов им. М.П.Чумакова</institution></aff></aff-alternatives><aff-alternatives id="aff2"><aff><institution xml:lang="en">Russian Medical Academy of Continuous Professional Education, Mechnikov Research Institute of Vaccines and Sera</institution></aff><aff><institution xml:lang="ru">Российская медицинская академия непрерывного профессионального образования, НИИ вакцин и сывороток им. И.И.Мечникова</institution></aff></aff-alternatives><aff-alternatives id="aff3"><aff><institution xml:lang="en">Chumakov Institute of Poliomyelitis and Viral Encephalitides,Scientific-Practical Centre of Medical Aid to Children with Development Diseases of Maxillofacial Region and Congenital Diseases of the Nervous System</institution></aff><aff><institution xml:lang="ru">Институт полиомиелита и вирусных энцефалитов им. М.П.Чумакова, НПЦ медицинской помощи детям с пороками развития челюстно-лицевой области и врожденными заболеваниями нервной системы ДЗМ</institution></aff></aff-alternatives><aff-alternatives id="aff4"><aff><institution xml:lang="en">Sechenov First Moscow State Medical University</institution></aff><aff><institution xml:lang="ru">Первый московский государственный медицинский университет им. И.М.Сеченова</institution></aff></aff-alternatives><aff-alternatives id="aff5"><aff><institution xml:lang="en">Administration of Rospotrebnadzor for the Sakha (Yakutia) Republic</institution></aff><aff><institution xml:lang="ru">правление Роспотребнадзора по Республике Саха (Якутия)</institution></aff></aff-alternatives><aff-alternatives id="aff6"><aff><institution xml:lang="en">Centre for Hygiene and Prophylaxis for Sverdlovsk Region</institution></aff><aff><institution xml:lang="ru">Центр гигиены и эпидемиологии Свердловской области</institution></aff></aff-alternatives><aff-alternatives id="aff7"><aff><institution xml:lang="en">infectious Hospital</institution></aff><aff><institution xml:lang="ru">Инфекционная больница</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2017-06-28" publication-format="electronic"><day>28</day><month>06</month><year>2017</year></pub-date><volume>94</volume><issue>3</issue><issue-title xml:lang="ru"/><fpage>99</fpage><lpage>106</lpage><history><date date-type="received" iso-8601-date="2019-04-10"><day>10</day><month>04</month><year>2019</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2017, Soboleva N.V., Karlsen A.A., Kozhanova T.V., Kichatova V.S., Klushkina V.V., Isaeva O.V., Ignatyeva M.E., Romanenko V..., Oorzhak N.D., Malinnikova E.Y., Kyuregyan K.K., Mikhaylov M.I.</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2017, Соболева И.В., Карлсен А.А., Кожанова Т.В., Кичатова В.С., Клушкина В.В., Исаева О.В., Игнатьева М.Е., Романенко В.В., Ооржак Н.Д., Малинникова Е.Ю., Кюрегян К.К., Михайлов М.И.</copyright-statement><copyright-year>2017</copyright-year><copyright-holder xml:lang="en">Soboleva N.V., Karlsen A.A., Kozhanova T.V., Kichatova V.S., Klushkina V.V., Isaeva O.V., Ignatyeva M.E., Romanenko V..., Oorzhak N.D., Malinnikova E.Y., Kyuregyan K.K., Mikhaylov M.I.</copyright-holder><copyright-holder xml:lang="ru">Соболева И.В., Карлсен А.А., Кожанова Т.В., Кичатова В.С., Клушкина В.В., Исаева О.В., Игнатьева М.Е., Романенко В.В., Ооржак Н.Д., Малинникова Е.Ю., Кюрегян К.К., Михайлов М.И.</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/><license><ali:license_ref xmlns:ali="http://www.niso.org/schemas/ali/1.0/">https://creativecommons.org/licenses/by/4.0</ali:license_ref></license></permissions><self-uri xlink:href="https://microbiol.crie.ru/jour/article/view/167">https://microbiol.crie.ru/jour/article/view/167</self-uri><abstract xml:lang="en"><p>Aim. Determine the prevalence of antibodies to hepatitis C virus (anti-HCV) among conditionally healthy population of Russian Federation. Materials and methods. Sera samples obtained from conditionally healthy population of the Russian Federation from 5 geographically distant regions with different levels of morbidity for hepatitis C were studied: Sverdlovsk, Rostov, Moscow regions, Tyva and Sakha (Yakutia) Republics. 4764 samples were studied in total obtained from individuals of 10 age groups: younger than 1, 1 - 4, 5 - 9, 10 - 14,15 - 19, 20 - 29, 30 - 39, 40 - 49,50 - 59, olderthan 60 years. Anti-HCV were determined by commercial ELISA. Results. The total prevalence of anti-HCV in 5 regions of Russian Federation was 2.6% (126/4764). The highest frequency of detection of anti-HCV was detected in Tyva and Yakutia Republics and was 3.3%, in other regions this parameter varied from 1,7 (Moscow region) to 3% in Sverdlovsk region. Peak parameters of anti-HCV detection among population in various regions were connected with various age groups: olderthan 60 years in Tyva and Yakutia Republics (11 and 9.9%, respectively), 40 - 49 in Moscow region (6.2%), 1 - 4 and 30 - 39 years in Sverdlovsk region (5.9 and 4.9%, respectively) and 20 - 39 in Rostov region (3.9%). Conclusion. Results of anti-HCV detection in various age cohorts of conditionally healthy population of Russian Federation give evidence regarding high morbidity with HCV of almost all the age groups in the interval from 20 to older than 60 years. Age cohorts were detected in each of the studied regions for which inclusion into regional screening programs is feasible.</p></abstract><trans-abstract xml:lang="ru"><p>Цель. Определить распространенность антител к вирусу гепатита С (анти-ВГС) среди условно здорового населения РФ. Материалы и методы. Исследованы образцы сыворотки крови, полученные от условно здорового населения РФ из пяти географически удаленных регионов с разным уровнем заболеваемости гепатитом С: Свердловской, Ростовской, Московской областей, Республики Тыва и Республики Саха (Якутия). Всего исследовано 4764 образцов, полученных от лиц из 10 возрастных групп: меньше 1 года, 1 - 4 лет, 5 - 9 лет, 10-14 лет, 15-19 лет, 20 - 29 лет, 30 - 39 лет, 40 - 49 лет, 50 - 59 лет, старше 60 лет. Анти-ВГС определяли методом иммуноферментного анализа с коммерческими тест-системами. Результаты. Общая распространенность анти-ВГС в 5 регионах РФ составила 2,6% (1 26/4764). Наибольшая частота выявления анти-ВГС была выявлена в Республиках Тыва и Якутия и составила 3,3%, в остальных регионах данный показатель варьировал от I, 7% (Московская область) до 3% в Свердловской области. Пиковые показатели выявления анти-ВГС среди населения в разных регионах были приурочены к разным возрастным группам: &gt;60 лет в Республиках Тыва и Якутия (11 % и 9,9% соответственно), 40 - 49 лет в Московской области (6,2%), 1 - 4 года и 30 - 39 лет в Свердловской области (5,9 и 4,9% соответственно) и 20 - 39 лет в Ростовской области (3,9%). Заключение. Результаты выявления анти-ВГС в различных возрастных когортах условно здорового населения РФ свидетельствуют о высокой степени пораженное™ ВГС практически всех возрастных групп в интервале от 20 лет до &gt;60 лет. В каждом из обследованных регионов выявлены возрастные когорты, доя которых целесообразно включение в региональные скрининговые программы.</p></trans-abstract><kwd-group xml:lang="en"><kwd>hepatitis C</kwd><kwd>anti-HCV</kwd><kwd>age cohorts</kwd><kwd>diagnostics</kwd><kwd>screening</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>гепатит С</kwd><kwd>анти-ВГС</kwd><kwd>возрастные когорты</kwd><kwd>диагностика</kwd><kwd>скрининг</kwd></kwd-group></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>Вирусные гепатиты в Российской Федерации. Под ред. В.И.Покровского, А.Б.Жебруна. СПб, ФБУН НИИЭМ им. Пастера, 2013.</mixed-citation></ref><ref id="B2"><label>2.</label><mixed-citation>Рекомендации по диагностике и лечению взрослых больных гепатитом С. Министерство здравоохранения Российской Федерации. 2013 год. http://gepatit-c.ru/treatment/pdf/ hcv_rek_2013.pdf.</mixed-citation></ref><ref id="B3"><label>3.</label><mixed-citation>Armstrong G.L., Wasley A., Simard Е.Р. et al. The prevalence of hepatitis C virus infection in the United States, 1999 through 2002. Ann. Intern. Med. 2006, 144: 705-714.</mixed-citation></ref><ref id="B4"><label>4.</label><mixed-citation>Durham D.P., Skrip L.A., Bruce R.D. et al. The impact of enhanced screening and treatment on hepatitis C in the United States. Clin. Infect. Dis. 2016,62 (3): 298-304. doi: 10.1093/cid/ civ894.</mixed-citation></ref><ref id="B5"><label>5.</label><mixed-citation>Deuffic-Burban S., Deltenre P, Buti M. et al. Predicted effects of treatment for HCV infection vary among European countries. Gastroenterology. 2012, 143 (4): 974-985.</mixed-citation></ref><ref id="B6"><label>6.</label><mixed-citation>Gonzalez-Grande R., Jimenez-Perez M., Gonzalez Arjona C., Mostazo Torres J. New approaches in the treatment of hepatitis C. World J. Gastroenterol. 2016, 22 (4): 1421-32. doi: 10.3748/wjg.v22.i4.1421.</mixed-citation></ref><ref id="B7"><label>7.</label><mixed-citation>Global health sector strategy on viral hepatitis 2016-2021. World Health Organization, 2016. http://apps.who.int/iris/bitstream/10665/246177/l/WHO-HIV-2016.06-eng.pdf.</mixed-citation></ref><ref id="B8"><label>8.</label><mixed-citation>Lanini S., Easterbrook P.J., Zumla A., Ippolito G. hepatitis c: global epidemiology and strategies for control. Clin. Microbiol. Infect. 2016, Aug 10. pii: S1198-743X(16)30300-7. doi: 10.1016/j.cmi.2016.07.035.</mixed-citation></ref><ref id="B9"><label>9.</label><mixed-citation>Lemoine M., Nayagam S., Thursz M. Viral hepatitis in resource-limited countries and access to antiviral therapies: current and future challenges. Future Virol. 2013, 8 (4): 371-380.</mixed-citation></ref><ref id="B10"><label>10.</label><mixed-citation>McGarry L.J., PawarV.S., PanchmatiaH.R. et al. Economic model of a birth cohort screening program for hepatitis C virus. Hepatology. 2012, 55 (5): 1344-1355.</mixed-citation></ref><ref id="B11"><label>11.</label><mixed-citation>Mohd Hanafiah K., Groeger J., Flaxman A.D., Wiersma S.T. Global epidemiology of hepatitis C virus infection: new estimates of age-specific antibody to HCV seroprevalence. Hepatology. 2013,57(4): 1333-1342.</mixed-citation></ref><ref id="B12"><label>12.</label><mixed-citation>Smith B.D., Morgan R.L., Beckett G.A. et al. Centers for Disease Control and Prevention (CDC). Recommendations for the identification of chronic hepatitis C virus infection among persons bom during 1945-1965. MMWRRecomm. Rep. 2012,61 (No. RR-4): 1-32. Erratum in: MMWR Recomm Rep. 2012, 61: 886.</mixed-citation></ref><ref id="B13"><label>13.</label><mixed-citation>Wasley A., Alter M. J. Epidemiology of hepatitis C: geographic differences and temporal trends. Semin Liver Dis. 2000, 20: 1-16.</mixed-citation></ref></ref-list></back></article>
