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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="other" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Journal of microbiology, epidemiology and immunobiology</journal-id><journal-title-group><journal-title xml:lang="en">Journal of microbiology, epidemiology and immunobiology</journal-title><trans-title-group xml:lang="ru"><trans-title>Журнал микробиологии, эпидемиологии и иммунобиологии</trans-title></trans-title-group></journal-title-group><issn publication-format="print">0372-9311</issn><issn publication-format="electronic">2686-7613</issn><publisher><publisher-name xml:lang="en">Central Research Institute for Epidemiology</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">151</article-id><article-id pub-id-type="doi">10.36233/0372-9311-2017-2-110-115</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>REVIEWS</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>ОБЗОРЫ</subject></subj-group><subj-group subj-group-type="article-type"><subject></subject></subj-group></article-categories><title-group><article-title xml:lang="en">USE OF VIBRIO CHOLERAE SURFACE STRUCTURES FOR SPECIFIC PROPHYLAXIS AND DIAGNOSTICS OF CHOLERA</article-title><trans-title-group xml:lang="ru"><trans-title>ИСПОЛЬЗОВАНИЕ ПОВЕРХНОСТНЫХ СТРУКТУР ХОЛЕРНОГО ВИБРИОНА ДЛЯ СПЕЦИФИЧЕСКОЙ ПРОФИЛАКТИКИ И ДИАГНОСТИКИ ХОЛЕРЫ</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Ivanooa</surname><given-names>I. A.</given-names></name><name xml:lang="ru"><surname>Иванова</surname><given-names>И. А.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Mishankin</surname><given-names>B. N.</given-names></name><name xml:lang="ru"><surname>Мишанькин</surname><given-names>Б. Н.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Bespalova</surname><given-names>I. A.</given-names></name><name xml:lang="ru"><surname>Беспалова</surname><given-names>И. А.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Omelchenko</surname><given-names>N. D.</given-names></name><name xml:lang="ru"><surname>Омельченко</surname><given-names>H. Д.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Shipko</surname><given-names>E. S.</given-names></name><name xml:lang="ru"><surname>Шипко</surname><given-names>Е. С.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Filippenko</surname><given-names>A. V.</given-names></name><name xml:lang="ru"><surname>Филиппенко</surname><given-names>А. В.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><xref ref-type="aff" rid="aff1"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">Rostov-on-Don Research Institute for Plague Control</institution></aff><aff><institution xml:lang="ru">Ростовский-на-Дону научно-исследовательский противочумный институт</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2017-04-28" publication-format="electronic"><day>28</day><month>04</month><year>2017</year></pub-date><volume>94</volume><issue>2</issue><issue-title xml:lang="ru"/><fpage>110</fpage><lpage>115</lpage><history><date date-type="received" iso-8601-date="2019-04-10"><day>10</day><month>04</month><year>2019</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2017, Ivanooa I.A., Mishankin B.N., Bespalova I.A., Omelchenko N.D., Shipko E.S., Filippenko A.V.</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2017, Иванова И.А., Мишанькин Б.Н., Беспалова И.А., Омельченко H.Д., Шипко Е.С., Филиппенко А.В.</copyright-statement><copyright-year>2017</copyright-year><copyright-holder xml:lang="en">Ivanooa I.A., Mishankin B.N., Bespalova I.A., Omelchenko N.D., Shipko E.S., Filippenko A.V.</copyright-holder><copyright-holder xml:lang="ru">Иванова И.А., Мишанькин Б.Н., Беспалова И.А., Омельченко H.Д., Шипко Е.С., Филиппенко А.В.</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/><license><ali:license_ref xmlns:ali="http://www.niso.org/schemas/ali/1.0/">https://creativecommons.org/licenses/by/4.0</ali:license_ref></license></permissions><self-uri xlink:href="https://microbiol.crie.ru/jour/article/view/151">https://microbiol.crie.ru/jour/article/view/151</self-uri><abstract xml:lang="en"><p>The need for efficient and cost-effective cholera vaccine hasn’t lost its actuality in view of the emergence of new strains leading to severe clinical forms of cholera and capable to replace strains of the seventh cholera pandemic, and in connection with the threat of cholera spreading beyond the borders of endemic countries. In this review data from literature sources are presented about the use of outer membrane proteins, vesicles, cell ghosts of the cholera causative agent in specific prophylaxis and diagnostics of the disease.</p></abstract><trans-abstract xml:lang="ru"><p>Потребность в эффективной и экономичной вакцине против холеры продолжает оставаться актуальной в связи с появлением новых штаммов, которые вызывают тяжелые клинические формы холеры и могут вытеснить штаммы седьмой пандемии, а также угрозе выноса инфекции из эндемичных стран. В обзоре представлены литературные данные об использовании белков наружных мембран, везикул, «теней» возбудителя холеры для специфической профилактики и диагностики этого заболевания.</p></trans-abstract><kwd-group xml:lang="en"><kwd>«тени» возбудителя холеры</kwd><kwd>outer membrane proteins</kwd><kwd>vesicles</kwd><kwd>cell ghosts of cholera causative agent</kwd><kwd>vaccine</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>белки наружных мембран</kwd><kwd>везикулы</kwd><kwd>вакцина</kwd></kwd-group></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>Евдокимова В.В., Алексеева Л.П., Кретенчук О.Ф., Кругликов В.Д., Архангельская И.В., Бурша О.С. Моноклональные антитела к термостабильным поверхностным антигенам холерных вибрионов 01 и 0139-серогруппы. Эпидемиол. и инф. болезни. 2015, 20 (3): 51-57...</mixed-citation></ref><ref id="B2"><label>2.</label><mixed-citation>Заднова С.П., Топорков А.В., Смирнова Н.И. 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