Journal of microbiology, epidemiology and immunobiologyJournal of microbiology, epidemiology and immunobiologyЖурнал микробиологии, эпидемиологии и иммунобиологии0372-93112686-7613Central Research Institute for Epidemiology1510.36233/0372-9311-2016-1-79-89REVIEWSОБЗОРЫPERSPECTIVES OF DEVELOPMENT OF LIVE RECOMBINANT ANTHRAX VACCINES BASED ON OPPORTUNISTIC AND APATHOGENIC MICROORGANISMSПЕРСПЕКТИВЫ РАЗРАБОТКИ ЖИВЫХ РЕКОМБИНАНТНЫХ СИБИРЕЯЗВЕННЫХ ВАКЦИН НА ОСНОВЕ УСЛОВНО ПАТОГЕННЫХ И НЕПАТОГЕННЫХ МИКРООРГАНИЗМОВPopovaP. Yu.ПоповаП. Ю.
Russian Federation
MikshisN. I.МикшисН. И.
Russian Federation
Russian Research Institute for Plague Control «Microbe»Российский научно-исследовательский противочумный институт «Микроб»28022016931798910042019Copyright ©; 2016, Popova P.Y., Mikshis N.I.Copyright ©; 2016, Попова П.Ю., Микшис Н.И.2016Popova P.Y., Mikshis N.I.Попова П.Ю., Микшис Н.И.https://creativecommons.org/licenses/by/4.0https://microbiol.crie.ru/jour/article/view/15

Live genetic engineering anthrax vaccines on the platform of avirulent and probiotic micro-ogranisms are a safe and adequate alternative to preparations based on attenuated Bacillus anthracis strains. Mucosal application results in a direct contact of the vaccine preparations with mucous membranes in those organs and tissues of the macro-organisms, that are exposed to the pathogen in the first place, resulting in a development of local and systemic immune response. Live recombinant anthrax vaccines could be used both separately as well as in a prime-boost immunization scheme. The review focuses on immunogenic and protective properties of experimental live genetic engineering preparations, created based on members ofgeni of Salmonella, Lactobacillus and adenoviruses.

Живые генно-инженерные сибиреязвенные вакцины на платформе авирулентных и пробиотических микроорганизмов являются безопасной и адекватной альтернативой препаратам на основе аттенуированных штаммов Bacillus anthracis. Мукозальная аппликация приводит к непосредственному контакту вакцинных препаратов со слизистыми оболочками в тех органах и тканях макроорганизма, которые в первую очередь подвергаются воздействию патогена, приводя к развитию местного и системного иммунного ответа. Живые рекомбинантные сибиреязвенные вакцины могут применяться как самостоятельно, так и в схеме прайм-бустерной иммунизации. В обзоре сделан акцент на иммуногенных и протективных свойствах экспериментальных живых генно-инженерных препаратов, созданных на основе представителей родов Salmonella, Lactobacillus и аденовирусов.

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