Journal of microbiology, epidemiology and immunobiologyJournal of microbiology, epidemiology and immunobiologyЖурнал микробиологии, эпидемиологии и иммунобиологии0372-93112686-7613Central Research Institute for Epidemiology14096ArticlesСтатьиReview ArticleADHESION OF CORYNEBACTERIUM DIPHTHERIAE: THE ROLE OF SURFACE STRUCTURES AND FORMATION MECHANISMАДГЕЗИЯ CORYNEBACTERIUM DIPHTHERIAE: РОЛЬ ПОВЕРХНОСТНЫХ СТРУКТУР И МЕХАНИЗМ ФОРМИРОВАНИЯKharseevaG. GХарсееваГ. ГAlievaA. AАлиеваА. АRostov State Medical University, Rostov-on-Don, RussiaРостовский государственный медицинский университет, Ростов-на-Дону15082014914NO4 (2014)№4 (2014)10911709062023Copyright ©; 2014, Kharseeva G.G., Alieva A.A.Copyright ©; 2014, Харсеева Г.Г., Алиева А.А.2014Kharseeva G.G., Alieva A.A.Харсеева Г.Г., Алиева А.А.https://creativecommons.org/licenses/by/4.0https://microbiol.crie.ru/jour/article/view/14096

The paper is devoted to the study of surface structures including pili (fimbriae) 67-72p surface protein, DIP 1281 surface protein, lipoarabinomannan CdiLAM and their role in the adhesion and colonization of the mucous membrane of the throat by Corynebacterium diphtheriaе. A description is offered for the main stages in the adhesion process of diphtheria causative agent and the ability of its adhesins to stimulate the effect of innate and acquired immunity factors. The paper stresses prospectiveness of the development of vaccines forming immunoprotection of the organism against adhesive activity of С. diphtheriaе and also preventing their colonization and reproduction. That would facilitate a solution for the problem of diphtheria carrier state, which cannot be solved using the existing means of preventive vaccination.

Рассмотрено строение поверхностных структур, включая пили (фимбрии), поверхностный белок 67-72р, поверхностный белок DIP 1281, липоарабиноманнан CdiLAM и их роль в процессах адгезии и колонизации Corynebacterium diphtheriaе слизистой оболочки зева. Описаны основные этапы адгезии возбудителя дифтерии, а также способность его адгезинов стимулировать действие факторов врожденного и приобретенного иммунитета. Подчеркнута перспективность создания вакцин, формирующих иммунологическую защиту организма от адгезивной активности С. diphtheriaе, а также препятствующих их колонизации и размножению. Это позволило бы решить проблему дифтерийного бактерионосительства, справиться с которой существующими средствами вакцинопрофилактики невозможно.

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