Journal of microbiology, epidemiology and immunobiologyJournal of microbiology, epidemiology and immunobiologyЖурнал микробиологии, эпидемиологии и иммунобиологии0372-93112686-7613Central Research Institute for Epidemiology14095ArticlesСтатьиReview ArticleANTIMICROBIAL COMPOUNDS OF ENTEROCOCCIАНТИМИКРОБНЫЕ СОЕДИНЕНИЯ ЭНТЕРОКОККОВValyshevA. VВалышевА. ВResearch Institute of Cellular and Intracellular Symbiosis, Orenburg, RussiaИнститут клеточного и внутриклеточного симбиоза, Оренбург15102014915NO5 (2014)№5 (2014)11912609062023Copyright ©; 2014, Valyshev A.V.Copyright ©; 2014, Валышев А.В.2014Valyshev A.V.Валышев А.В.https://creativecommons.org/licenses/by/4.0https://microbiol.crie.ru/jour/article/view/14095

The main studies of a group of antimicrobial compounds produced by Enterococcus genus bacteria: bacteriocins, organic acids, activated oxygen metabolites, enzymes, exopolysaccharides - are described in the review. Data on synergic interaction of these substances in killing of pathogens, formation of active substances from different components as a result of metabolic activity of enterococci are presented. Production of these compounds is a reflection of competitive habitation ofbacteria under the conditions of multi-species microbiomes and ensures colonization resistance of host biotopes. A complementation of the group of bacterial antimicrobial compounds by compounds that do not have a direct effect on the growth of microorganisms but suppress pathogenic potential of infectious disease causative agents is assumed.

В обзоре описаны основные исследованные группы антимикробных соединений, продуцируемые бактериями рода Enterococcus: бактериоцины, органические кислоты, активированные кислородные метаболиты, ферменты, экзополисахариды. Приводятся данные о синергидном взаимодействии таких веществ в киллинге патогенов, образовании активных субстанций из различных компонентов в результате метаболической активности энтерококков. Продукция этих соединений является отражением конкурентного обитания бактерий в условиях мультивидовых микробиомов и обеспечивает колонизационную резистентность биотопов хозяина. Предлагается дополнение группы бактериальных антимикробных соединений за счет веществ, не обладающих прямым влиянием на рост микроорганизмов, но подавляющих патогенный потенциал возбудителей инфекционных заболеваний.

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