Journal of microbiology, epidemiology and immunobiology

Журнал микробиологии, эпидемиологии и иммунобиологии

0372-93112686-7613

Central Research Institute for Epidemiology

14089

Articles

Статьи

Review Article

MECHANISMS OF MICROORGANISM RESISTANCE TO β-LACTAM ANTIBIOTICS

МЕХАНИЗМЫ РЕЗИСТЕНТНОСТИ МИКРООРГАНИЗМОВ К β-ЛАКТАМНЫМ АНТИБИОТИКАМ

Dyachkova

V. S

Дьячкова

В. С

Bazhukova

T. A

Бажукова

Т. А

Northern State Medical University, Arkhangelsk, RussiaСеверный государственный медицинский университет, Архангельск

15082014

914

NO4 (2014)

№4 (2014)

10110909062023

2014

Dyachkova V.S., Bazhukova T.A.

Дьячкова В.С., Бажукова Т.А.

https://creativecommons.org/licenses/by/4.0

https://microbiol.crie.ru/jour/article/view/14089

Literature data on molecular mechanisms of resistance to β-lactam antibiotics have been summarized. The following mechanisms are examined: appearance of penicillin-binding proteins (PBP) with lower affinity to β-lactam antibiotics; production by microorganisms of enzymes β-lactamases) that hydrolyze β-lactam ring; disruption of microbial cell outer membrane permeability and active secretion of antibiotics from the microbial cell (efflux-effect). Characterization of extended spectrum β-lactamases (ESBL) as well as data on structure of SCCmec element of MRSA and bacterial efflux system (RND) is presented.

Обобщены данные литературы по молекулярным механизмам антибиотикорезистентности к β-лактамным антибиотикам. Рассмотрены следующие механизмы: появление пенициллинсвязывающих белков (ПСБ) со сниженной аффиностью к β-лактамным антибиотикам; продукция микроорганизмами ферментов β-лактамаз), гидролизующих β-лактамное кольцо; нарушение проницаемости внешней мембраны микробной клетки и активное выведение антибиотиков из микробной клетки (эффлюкс-система). Представлена характеристика β-лактамаз расширенного спектра (БЛРС), а также данные о структуре SCCmec элемента MRSA и бактериальной системы эффлюкса (RND).

antibiotic resistancemecA geneESBLeffluxporin

антибиотикорезистентностьmecА генБЛРСэффлюкспорины

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