Journal of microbiology, epidemiology and immunobiologyJournal of microbiology, epidemiology and immunobiologyЖурнал микробиологии, эпидемиологии и иммунобиологии0372-93112686-7613Central Research Institute for Epidemiology14084ArticlesСтатьиReview ArticlePNEUMOCOCCAL BIOFILMS AS A FORM OF PERSISTENCE: FORMATION, STRUCTURE, ROLE IN PATHOGENESIS, IMMUNE RESPONSEПНЕВМОКОККОВЫЕ БИОПЛЕНКИ КАК ФОРМА ПЕРСИСТЕНЦИИ: ОБРАЗОВАНИЕ, СТРУКТУРА, РОЛЬ В ПАТОГЕНЕЗЕ, ИММУННЫЙ ОТВЕТKostyukovaN. NКостюковаН. НBekhaloV. AБехалоВ. АGamaleya Federal Research Centre of Epidemiology and MicrobiologyФедеральный научно-исследовательский центр эпидемиологии и микробиологии им. Н.Ф.Гамалеи15082015924NO4 (2015)№4 (2015)556209062023Copyright ©; 2015, Kostyukova N.N., Bekhalo V.A.Copyright ©; 2015, Костюкова Н.Н., Бехало В.А.2015Kostyukova N.N., Bekhalo V.A.Костюкова Н.Н., Бехало В.А.https://creativecommons.org/licenses/by/4.0https://microbiol.crie.ru/jour/article/view/14084

A review of studies on pneumococcal biofilms as a form of persistence is presented. The following provisions are examined: formation of pneumococcal biofilm on abiotic and mucosal surfaces, pathogenetic significance of biofilm pneumococci, their immunogenicity, as well as resistance to antibiotics and unfavorable environmental factors. Differences between biofilm properties, that are formed in vivo and in vitro, are shown. The significance of pneumococcal biofilm formation as means of survival for a long time is underscored.

Представлен обзор работ о пневмококковых биопленках как форме персистенции. Рассмотрены следующие положения: формирование пневмококковой биопленки на абиотических и мукозных поверхностях, патогенетическое значение биопленочных пневмококков, их иммуногенность, а также устойчивость к антибиотикам и неблагоприятным факторам внешней среды. Показаны различия между свойствами биопленок, образованных in vivo и in vitro. Подчеркивается значение образования пневмококковой биопленки как способа выживания в течение длительного времени.

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