Journal of microbiology, epidemiology and immunobiologyJournal of microbiology, epidemiology and immunobiologyЖурнал микробиологии, эпидемиологии и иммунобиологии0372-93112686-7613Central Research Institute for Epidemiology13917ArticlesСтатьиReview ArticleINTESTINE INFECTIONS, INFLAMMATION AND AUTOIMMUNITY. LYMPHOID APPARATUS OF INTESTINE IN INTERACTION WITH INTESTINE MICROFLORAКИШЕЧНЫЕ ИНФЕКЦИИ, ВОСПАЛЕНИЕ И АУТОИММУНИТЕТ. ЛИМФОИДНЫЙ АППАРАТ КИШЕЧНИКА ВО ВЗАИМОДЕЙСТВИИ С КИШЕЧНОЙ МИКРОФЛОРОЙBalmasovaI. PБалмасоваИ. ПSepiashviliR. IСепиашвилиР. ИRussian University of Peoples’ Friendship, Moscow, RussiaРоссийский университет дружбы народов, Москва15022013901NO1 (2013)№1 (2013)11312009062023Copyright ©; 2013, Balmasova I.P., Sepiashvili R.I.Copyright ©; 2013, Балмасова И.П., Сепиашвили Р.И.2013Balmasova I.P., Sepiashvili R.I.Балмасова И.П., Сепиашвили Р.И.https://creativecommons.org/licenses/by/4.0https://microbiol.crie.ru/jour/article/view/13917

Topicality of interrelation between intestine infections, inflammation diseases of intestine and autoimmune processes is widely discussed in scientific literature of recent years. Thereby a review of literature on the designated aspect of the problem is dedicated to the analysis of interconnection between structural-functional features of lymphoid apparatus of intestine and its ability to react to antigen load from both commensal and pathogenic intestine microflora. During description of structure and functions of lymphoid formation of intestine a particular attention is paid to difference of subpopulation characteristics of lymphocytes and antigen-presenting cells composing intra-epithelial lymphocytes, elements of immune system lamina propria , Peyer’s patches, mesenteric lymphatic nodes. The role of normal microflora and infectious agents in trigger mechanisms of reaction of immunocompetent cells is underscored; key aspects of cellular-molecular mechanisms of mucous membrane immune system functions are discussed.

Актуальность взаимосвязи между кишечными инфекциями, воспалительными заболеваниями кишечника и аутоиммунными процессами широко обсуждается в научной литературе последних лет. Обзор литературы по обозначенному аспекту проблемы посвящен анализу взаимосвязи между структурно-функциональными особенностями лимфоидного аппарата кишечника и его способностью реагировать на антигенную нагрузку со стороны как комменсальной, так и патогенной кишечной микрофлоры. При описании структуры и функций лимфоидных образований кишечника особое внимание уделяется различию субпопуляционных характеристик лимфоцитов и антигенпрезентирующих клеток в составе интраэпителиальных лимфоцитов, элементов иммунной системы lamina propria, пейеровых бляшек, мезентериальных лимфатических узлов. Подчеркивается роль нормальной микрофлоры и инфекционных агентов в пусковых механизмах реагирования иммунокомпетентных клеток, обсуждаются ключевые аспекты клеточно-молекулярных механизмов функционирования иммунной системы слизистых оболочек кишечника.

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