Journal of microbiology, epidemiology and immunobiologyJournal of microbiology, epidemiology and immunobiologyЖурнал микробиологии, эпидемиологии и иммунобиологии0372-93112686-7613Central Research Institute for Epidemiology13907ArticlesСтатьиReview ArticleNEUTROPHILS AND BACTERIAL BIOFILMS: DIALECTICS OF RELATIONSHIPНЕЙТРОФИЛЫ И БАКТЕРИАЛЬНЫЕ БИОПЛЕНКИ: ДИАЛЕКТИКА ВЗАИМООТНОШЕНИЙChebotarI. VЧеботарьИ. ВMayanskyA. NМаянскийА. НKonchakovaE. DКончаковаЕ. ДNizhny Novgorod State Medical Academy, Russia15122013906NO6 (2013)№6 (2013)10511209062023Copyright ©; 2013, Chebotar I.V., Mayansky A.N., Konchakova E.D.Copyright ©; 2013, Чеботарь И.В., Маянский А.Н., Кончакова Е.Д.2013Chebotar I.V., Mayansky A.N., Konchakova E.D.Чеботарь И.В., Маянский А.Н., Кончакова Е.Д.https://creativecommons.org/licenses/by/4.0https://microbiol.crie.ru/jour/article/view/13907

The review is dedicated to the problem of interaction of human neutrophils with bacterial biofilms that complicate the course of infectious process. Neutrophils being the most important effectors of innate immunity may attack bacterial biofilms causing their rejections and damage of biofilm microbes. Mechanisms of neutrophil-dependent destruction of biofilms are analyzed in the review. Variants of defense of biofilm bacteria from phagocytosis that are used by them for evading neutrophils and consolidation of biofilm structures are discussed.

Обзор посвящен проблеме взаимодействия нейтрофилов человека с бактериальными биопленками, осложняющими течение инфекционного процесса. Нейтрофилы, являясь важнейшими эффекторами врожденного иммунитета, могут атаковать бактериальные биопленки, вызывая их отторжение и повреждение биопленочных микробов. В обзоре проанализированы механизмы нейтрофил-зависимой деструкции биопленок. Обсуждаются варианты защиты биопленочных бактерий от фагоцитоза, которые используются ими для ускользания от нейтрофилов и укрепления биопленочных структур.

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