Journal of microbiology, epidemiology and immunobiologyJournal of microbiology, epidemiology and immunobiologyЖурнал микробиологии, эпидемиологии и иммунобиологии0372-93112686-7613Central Research Institute for Epidemiology13897ArticlesСтатьиReview ArticlePROTEIN COMPONENTS OF INNATE IMMUNITY IN PROTECTION FROM PATHOGENIC INVASION (LITERATURE REVIEW)БЕЛКОВЫЕ КОМПОНЕНТЫ ВРОЖДЕННОГО ИММУНИТЕТА В ЗАЩИТЕ ОТ ПАТОГЕННОЙ ИНВАЗИИZorinaV. NЗоринаВ. НZorinN. AЗоринН. АNovokuznetsk State Institute for Physicians Development, RussiaНовокузнецкий государственный институт усовершенствования врачей15062013903NO3 (2013)№3 (2013)11111709062023Copyright ©; 2013, Zorina V.N., Zorin N.A.Copyright ©; 2013, Зорина В.Н., Зорин Н.А.2013Zorina V.N., Zorin N.A.Зорина В.Н., Зорин Н.А.https://creativecommons.org/licenses/by/4.0https://microbiol.crie.ru/jour/article/view/13897

System of innate immunity is a set of effector molecules and cells counteracting invasion of pathogens and their products. AIpha-2-macroglobulin (a2-MG) and lactoferrin (LF) play a significant role in primary protection of organism. A wide spectrum of transport and regulatory functions, high affinity to endocytosis receptor as well as structural features of these proteins allow them not only to effectively protect the organism during direct contact with pathogen but also to have an immunomodulatory impact on immunocompetent cells of adaptive immunity. However despite a common receptor and a number of ligands, mechanisms of realization of protective functions of a2-MG and LF differ significantly. The aim of this review is to system-ize knowledge on means and mechanisms of protection of a2-MG and LF against invasion.

Система врожденного иммунитета представляет собой набор эффекторных молекул и клеток, противодействующих инвазии патогенов и их продуктов. Альфа-2-макроглобулин (а2-МГ) и лак-тоферрин (ЛФ) играют значительную роль в первичной защите организма. Широкий спектр транспортных и регуляторных функций, высокое сродство к рецептору эндоцитоза, а также структурные особенности данных белков позволяют им не только эффективно защищать организм при непосредственном контакте с патогеном, но и оказывать модулирующее воздействие на иммунокомпе-тентные клетки адаптивного иммунитета. Однако, несмотря на общий рецептор и ряд лигандов, механизмы реализации защитных функций а2-МГ и ЛФ значительно различаются. Цель данного обзора - систематизация знаний о способах и механизмах защиты а2-МГ и ЛФ от патогенной инвазии.

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