Journal of microbiology, epidemiology and immunobiologyJournal of microbiology, epidemiology and immunobiologyЖурнал микробиологии, эпидемиологии и иммунобиологии0372-93112686-7613Central Research Institute for Epidemiology13748ArticlesСтатьиINFLUENCE OF STRESSORS ON FORMATIONOF UNCULTURED MICROORGANISM FORMSAND THEIR RECOVERYВЛИЯНИЕ СТРЕССОРОВ НА ОБРАЗОВАНИЕНЕКУЛЬТИВИРУЕМЫХ ФОРМ МИКРООРГАНИЗМОВ И ИХ ВОССТАНОВЛЕНИЕMel'nikovaV AМельниковаВ А

НИИ вакцин и сывороток им. И.И.Мечни-кова, Москва

MikhaylovaN AМихайловаН А

НИИ вакцин и сывороток им. И.И.Мечни-кова, Москва

VartanovaN OВартановаН О

НИИ вакцин и сывороток им. И.И.Мечни-кова, Москва

MelnikovaV A

Mechnikov Research Institute of Vaccines andSera, Moscow, Russia

MikhaylovaN A

Mechnikov Research Institute of Vaccines andSera, Moscow, Russia

VartanovaN O

Mechnikov Research Institute of Vaccines andSera, Moscow, Russia

НИИ вакцин и сывороток им. И.И.Мечни-кова, МоскваMechnikov Research Institute of Vaccines andSera, Moscow, Russia15062012892NO2 (2012)№2 (2012)10911609062023Copyright ©; 2012, Mel'nikova V.A., Mikhaylova N.A., Vartanova N.O., Melnikova V.A., Mikhaylova N.A., Vartanova N.O.Copyright ©; 2012, Мельникова В.А., Михайлова Н.А., Вартанова Н.О., Melnikova V.A., Mikhaylova N.A., Vartanova N.O.2012Mel'nikova V.A., Mikhaylova N.A., Vartanova N.O., Melnikova V.A., Mikhaylova N.A., Vartanova N.O.Мельникова В.А., Михайлова Н.А., Вартанова Н.О., Melnikova V.A., Mikhaylova N.A., Vartanova N.O.https://creativecommons.org/licenses/by/4.0https://microbiol.crie.ru/jour/article/view/13748

Data of the last decade on the studies of influence of various inductors of microorganism uncultured state and reasons of reversion that include not only effect of appropriate cultivation conditions but also simple cancellation of unfavorable effects are analyzed. Reasons for transition to uncultured state are discussed; those could be a variety of factors such as heat, alkaline, acid and osmotic stress. Factors that promote recovery from uncultured state with the main being Rpf (Resustication promoting factor) factor isolated from Micrococcus luteus and cancellation of endogenic peroxide effect by addition of catalase and sodium pyruvate are analyzed.

Проанализированы данные по влиянию различных индукторов некультивируемого состояния микроорганизмов и причин реверсии, включающих не только действие подходящих условий выращивания, но и просто отмену неблагоприятных воздей- ствий. Обсуждаются причины перехода в некультивируемое состояние, которыми может служить многообразие факторов, таких как тепловой, щелочной, кислотный или осмотический стрессы. Анализируются факторы, способствующие восстановлению из некультивируемого состояния, основ- ными из которых являются фактор Rpf, выделенный из Micrococcus luteus, и отме- на действия эндогенных перекисей путем добавления каталазы или пирувата на- трия.

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