Journal of microbiology, epidemiology and immunobiologyJournal of microbiology, epidemiology and immunobiologyЖурнал микробиологии, эпидемиологии и иммунобиологии0372-93112686-7613Central Research Institute for Epidemiology13371ArticlesСтатьиReview ArticleMECHANISMS OF CHLAMYDIA TRACHOMATIS AND HERPES SIMPLEX VIRUS PERSISTENCE DURING VIRAL-BACTERIAL INFECTIONМЕХАНИЗМЫ ПЕРСИСТЕНЦИИ CHLAMYDIA TRACHOMATIS И ВИРУСА ПРОСТОГО ГЕРПЕСА ПРИ ВИРУСНО-БАКТЕРИАЛЬНОЙ ИНФЕКЦИИBekhaloV. AБехалоВ. АSysolyatinaE. VСысолятинаЕ. ВNagurskayaE. VНагурскаяЕ. ВGamaleya Research Institute of Epidemiology and Microbiology, Moscow, RussiaНИИ эпидемиологии и микробиологии им. Н.Ф.Гамалеи, Москва15102009865NO5 (2009)№5 (2009)10511009062023Copyright ©; 2009, Bekhalo V.A., Sysolyatina E.V., Nagurskaya E.V.Copyright ©; 2009, Бехало В.А., Сысолятина Е.В., Нагурская Е.В.2009Bekhalo V.A., Sysolyatina E.V., Nagurskaya E.V.Бехало В.А., Сысолятина Е.В., Нагурская Е.В.https://creativecommons.org/licenses/by/4.0https://microbiol.crie.ru/jour/article/view/13371

Possible mechanisms of persistence on the example of Chlamydia trachomatis in conditions of herpes simplex virus type 2 (HSV-2) superinfection in vitro and in vivo are described. Emergence of persisting forms of Chlamydia as well as factors influencing on this process are considered. Contemporary views on pathogenesis of viralbacterial infection with HSV-2 and C.trachomatis as well as interactions of the agents with local immunity factors are described. It was suggested that there are signaling pathways through which HSV-2 changes life cycle of Chlamydia .

Приводятся возможные механизмы персистенции на примере Chlamydia trachomatis в условиях суперинфекции вируса простого герпеса 2 типа (ВПГ-2) in vitro и in vivo. Рассмотрены формирование персистирующих форм хламидий и факторы, влияющие на этот процесс. Приведены современные представления о патогенезе вирусно-бактериальной инфекции ВПГ-2 и C.trachomatis и взаимодействии возбудителей с факторами местного иммунитета. Высказано предположение о существовании сигнальных путей, посредством которых ВПГ-2 изменяет жизненный цикл хламидий.

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